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J Pediatr Genet 2015; 04(02): 071-083
DOI: 10.1055/s-0035-1556739
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Update on Prepregnancy Maternal Obesity: Birth Defects and Childhood Outcomes

Noha Iessa
1   Faculty of Pharmacy, University of Montreal, Montreal, Québec, Canada
2   Research Center, CHU Sainte-Justine, Montreal, Québec, Canada
,
Anick Bérard
1   Faculty of Pharmacy, University of Montreal, Montreal, Québec, Canada
2   Research Center, CHU Sainte-Justine, Montreal, Québec, Canada
› Author Affiliations
Further Information

Publication History

19 January 2015

25 January 2015

Publication Date:
31 July 2015 (online)

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Abstract

Obesity is a growing global health epidemic. It is estimated that more than 20% of pregnancies are complicated by obesity. Prepregnancy obesity has been associated with birth defects such as neural tube defects, macrosomia, fetal death, and long-term effects such as asthma on the offspring. We provide a summary of the most recent studies and meta-analyses on obesity and birth outcome. Possible mechanisms of actions are explored and recommendations for further research are highlighted.

Keywords

obesity - body mass index - pregnancy - major congenital malformations
 

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