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Am J Perinatol 2015; 32(13): 1231-1239
DOI: 10.1055/s-0035-1552934
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Features of Neonates with Hydrops Fetalis

Xiaoxia An
1   Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Jimei Wang
1   Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
2   Department of Prenatal Diagnosis Center, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Xiaolei Zhuang
1   Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Jiale Dai
1   Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Chengqiu Lu
1   Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Xiaotian Li
2   Department of Prenatal Diagnosis Center, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
,
Yingliu Yan
2   Department of Prenatal Diagnosis Center, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
› Author Affiliations
Further Information

Publication History

24 January 2015

30 March 2015

Publication Date:
12 June 2015 (online)

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Abstract

Objective The objective of this study was to evaluate the clinical characteristics of neonates with hydrops fetalis to improve recognition of the disease.

Patients and Methods The clinical data of 10 neonates with hydrops fetalis were retrospectively studied. Prenatal characteristics, causes, clinical features, and prognosis were explored.

Results Eight neonates presenting abnormal nonstress test suffered from severe neonatal asphyxia at birth and were resuscitated by endotracheal intubation. Nine had skin edema, eight had pleural effusions with one unilateral and seven bilateral. Six had ascites, eight had polyhydramnios, one had multiple malformations and one had chromosome abnormalities. One survived and nine died. Six died due to resuscitation failure in delivery room, two died due to giving up after 1 day and one died due to the treatment failure after 6 months. Causes of hydrops fetalis were a congenital diaphragmatic hemangioma, recurrent atrial premature beats, genetic syndrome suspicious, Down syndrome, congenital pulmonary lymphangiectasia, anemia, paroxysmal supraventricular tachycardia, placental chorioangioma, and idiopathic edema.

Conclusion The prognosis varied because of different etiologies of hydrops fetalis. Severe cases frequently had skin edema and high rate of asphyxia at birth and difficult resuscitation. Timely intrauterine interventions were helpful for successful resuscitation. A well-prepared resuscitation team and the effectiveness of resuscitation could correlate to increasing survival rate.

Keywords

hydrops fetalis - ultrasound - neonate - pleural effusions
 

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