Int J Angiol 2016; 25(05): e121-e122
DOI: 10.1055/s-0035-1548548
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter

Dale Murdoch
1   Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia
2   School of Medicine, The University of Queensland, Brisbane, Australia
,
William O'Callaghan
3   Department of Endocrinology, Gold Coast University Hospital, Gold Coast, Australia
,
Elham Reda
3   Department of Endocrinology, Gold Coast University Hospital, Gold Coast, Australia
,
Selvanayagam Niranjan
3   Department of Endocrinology, Gold Coast University Hospital, Gold Coast, Australia
4   School of Medicine, Griffith University, Gold Coast, Australia
› Author Affiliations
Further Information

Publication History

Publication Date:
23 March 2015 (online)

Abstract

Takotsubo cardiomyopathy is increasingly recognized as a distinct clinical entity. An association with thyroid disease has been identified in several case reports, mostly in the context of Grave disease. We report the case of a 67-year-old woman presenting with takotsubo cardiomyopathy and thyrotoxicosis secondary to toxic multinodular goiter. Previously unreported, this suggests that this association is related to the direct effects of thyroid hormone, rather than an autoimmune mechanism. Thyroid disease should be considered in patients presenting with takotsubo cardiomyopathy.

 
  • References

  • 1 Miyazaki S, Kamiishi T, Hosokawa N , et al. Reversible left ventricular dysfunction “takotsubo” cardiomyopathy associated with hyperthyroidism. Jpn Heart J 2004; 45 (5) 889-894
  • 2 Rossor AM, Pearce SH, Adams PC. Left ventricular apical ballooning (takotsubo cardiomyopathy) in thyrotoxicosis. Thyroid 2007; 17 (2) 181-182
  • 3 Radhakrishnan A, Granato JE. An association between Takotsubo cardiomyopathy and thyroid storm. Postgrad Med 2009; 121 (3) 126-130
  • 4 Sarullo FM, Americo L, Accardo S , et al. Tako-tsubo cardiomyopathy observed in a patient with sepsis and transient hyperthyroidism. Monaldi Arch Chest Dis 2009; 72 (1) 33-36
  • 5 Alidjan F, Ezzhati M, Bruggeling W, van Guldener C. Takotsubo cardiomyopathy precipitated by thyrotoxicosis. Thyroid 2010; 20 (12) 1427-1428
  • 6 Sakaki T, Fujioka Y, Akagami T , et al. Cardiac wall motion abnormalities observed in a patient with transient hyperthyroidism. Jpn Heart J 2004; 45 (6) 1071-1077
  • 7 van de Donk NW, America YG, Zelissen PM, Hamer BJ. Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre. Neth J Med 2009; 67 (10) 350-352
  • 8 Kwon SA, Yang JH, Kim MK , et al. A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. Int J Cardiol 2010; 145 (3) e111-e113
  • 9 Cakir M. Takotsubo cardiomyopathy in thyrotoxicosis. Int J Cardiol 2010; 145 (3) 499-500
  • 10 Wittstein IS, Thiemann DR, Lima JAC , et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005; 352 (6) 539-548
  • 11 Hoit BD, Khoury SF, Shao Y, Gabel M, Liggett SB, Walsh RA. Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. Circulation 1997; 96 (2) 592-598
  • 12 Bachman ES, Hampton TG, Dhillon H , et al. The metabolic and cardiovascular effects of hyperthyroidism are largely independent of beta-adrenergic stimulation. Endocrinology 2004; 145 (6) 2767-2774