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Am J Perinatol 2015; 32(05): 461-468
DOI: 10.1055/s-0034-1390344
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Correlation of Continuous Glucose Monitoring Profiles with Pregnancy Outcomes in Nondiabetic Women

Joyce F. Sung
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, Colorado
,
Elizabeth A. Kogut
2   Department of Obstetrics and Gynecology, Stanford University, Stanford, California
,
Henry C. Lee
3   Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, California
,
Jana L. Mannan
4   Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, San Jose, California
,
Kasra Navabi
5   Division of Endocrinology and Metabolism, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico
,
M. Mark Taslimi
6   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, California
,
Yasser Y. El-Sayed
6   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, California
› Author Affiliations
Further Information

Publication History

29 January 2014

25 July 2014

Publication Date:
28 September 2014 (online)

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Abstract

Objective To determine whether hyperglycemic excursions detected by continuous glucose monitoring (CGM) correlate with birth weight percentile and other pregnancy outcomes, and whether CGM correlates better with these outcomes than a single glucose value from a 1-hour glucose challenge test (GCT).

Study Design This was a prospective observational study of 55 pregnant patients without preexisting diabetes, who wore a CGM device for up to 7 days, between 24 and 28 weeks' gestation. The area under the curve (AUC) of hyperglycemic excursions above various thresholds (110, 120, 130, 140, and 180 mg/dL) was calculated. These AUC values, and results from a standard 50-g GCT, were correlated with our primary outcome of birth weight percentile, and secondary outcomes of unplanned operative delivery, pregnancy complications, delivery complications, fetal complications, and neonatal complications.

Results A consistent correlation was seen between all AUC thresholds and birth weight percentile (r = 0.29, p < 0.05 for AUC-110, −120, −130, and −140; r = 0.25, p = 0.07 for AUC-180). This correlation was stronger than that of 1-hour oral GCT (r = −0.02, p = 0.88). There was no association between AUC values and other outcomes.

Conclusions Among nondiabetic pregnant patients, hyperglycemic excursions detected by CGM show a stronger correlation to birth weight percentile than blood glucose values obtained 1-hour after a 50-g oral GCT.

Keywords

birth weight - continuous glucose monitoring - pregnancy
 

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