Z Geburtshilfe Neonatol 2014; 218(04): 142-148
DOI: 10.1055/s-0034-1382068
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Schwangerenbetreuung bei Drogenkonsum

Substance Abuse and Pregnancy from an Obstetric Point of View
G. Huber
1   Klinik für Geburtshilfe und Frauenheilkunde der Universität Regensburg, Krankenhaus St. Hedwig, Regensburg
,
B. Seelbach-Göbel
1   Klinik für Geburtshilfe und Frauenheilkunde der Universität Regensburg, Krankenhaus St. Hedwig, Regensburg
› Author Affiliations
Further Information

Publication History

eingereicht 07 March 2014

angenommen nach Überarbeitung 27 May 2014

Publication Date:
15 August 2014 (online)

Zusammenfassung

Einleitung: In Deutschland werden jährlich ca. 2 000 Kinder drogenabhängiger Mütter geboren. Eine deutlich höhere Dunkelziffer bei drogenkonsumierenden Schwangeren ist zu befürchten. Durch Mischkonsum mit vielfältiger Auswirkung auf das Kind, sowie psychosozialer und körperlicher Besonderheiten der Schwangeren, stellt die Betreuung dieser Schwangerschaften suchttherapeutisch und geburtshilflich eine Herausforderung dar.

Methode: Selektive Literaturrecherche in Pubmed, Übersichtsartikel und Originalarbeiten aus den Jahren 2001–2013, sowie Stellungnahmen deutscher und internationaler Fachverbände und Kommissionen zum Thema. Die vorliegende Arbeit möchte Gynäkologen, Geburtshelfern und Neonatologen eine Hilfestellung für die komplexe peripartale Betreuung suchtkranker Frauen geben.

Ergebnisse: Neben der besonderen psychischen Situation der Schwangeren mit gehäufter psychiatrischer Komorbidität wie Depression und Angststörung, sind gynäkologische Komplika­tionen wie vorzeitige Wehentätigkeit, intrauterine fetale Wachstumsrestriktion und maternale Infektionskrankheiten bei der Schwangerenvorsorge zu bedenken. Die pharmakologische Komplexität der konsumierten Suchtstoffe und deren mögliche Auswirkung auf den Feten muss der Schwangeren erklärt werden. Die Opiatsubstitutionstherapie ist in der Schwangerschaft das ­Mittel der Wahl zur fetomaternalen Risikoreduktion und mütterlichen Stabilisierung. Eine ­Aufklärung der Mutter über das in bis zu 90% der Neugeborenen auftretende, neonatale Abstinenzsyndrom und das Stillen in Kombination mit Nikotinabusus und/oder Infektionskrankheiten der Entbundenen ist von Bedeutung.

Diskussion: Ein professioneller und empathischer Umgang des Frauenarztes mit den betroffenen Schwangeren ist eine wichtige Voraussetzung zur Risikominimierung für Mutter und Kind. Trotz interdisziplinärer Zusammenarbeit aller Hilfesysteme und Vermeidung von Stigmatisierung ist es bei den Hochrisikopatientinnen mit polyvalentem Abusus weiterhin schwierig, alle Schwangeren einer engmaschigen gynäkologischen Vorsorge zuzuführen.

Abstract

Introduction: In Germany we find about 2 000 newborns per year with a mother misusing drugs. It is to be feared that there is a substantial amount of underreported substance abuse in pregnant women. To care for these pregnancies from an obstetric point of view as well as from an addiction treatment point of view is a challenge for all health-care professionals, due to multiple drugs being used and the special psychosocial and health issues these mothers and babies ­present.

Method: A selective search was undertaken in Pubmed, retrieving reviews and original articles from 2001–2013, with consideration of statements, recommendations and guidelines from national and international associations and committees on the topic. This review is intended to assist gynaecologists, obstetricians and paediatricians during the complex peripartum care for the drug abusing pregnant patient.

Results: When offering obstetric care for these pregnancies, several issues have to be taken into account: the special psychological situation of the pregnant drug user, with frequent occurrence of psychiatric comorbidities like depression and anxiety disorders, as well as gynaecological complications like premature labour, intrauterine growth restriction and maternal infectious diseases. The pharmacological complexity of the substances abused and the possible side-effects on the foetus have to be explained to the mother. Maintenance medication for foetomaternal risk reduction and maternal stabilisation remains the state-of-the-art treatment. Furthermore, it is important to explain the neonatal abstinence syndrome to the mother as well as the result of breast-feeding in the presence of smoking and/or infectious diseases.

Discussion: Professionalism and empathy are needed from gynaecologists in order to achieve risk reduction for mother and child in substance-using pregnancies. However, in spite of close cooperation of all health-care professionals and avoidance of stigma, it will be difficult to offer good obstetric care to the high-risk patients with poly-drug abuse.

 
  • Literatur

  • 1 Fachverband Drogen und Rauschmittel e. V. Positionspapier Drogen-Schwangerschaft-Kind 2009 Internet: http://fdr-online.info/media/Texte/Positionspapier_D_S_K(1).pdf
  • 2 Die Drogenbeauftragte der Bundesregierung Drogen- und Suchtbericht. 2012. Internet: http://www.drogenbeauftragte.de/fileadmin/dateien-dba/Presse/Downloads/12-05-22_DrogensuchtBericht_2012.pdf
  • 3 Bell J, Harvey-Dodds L. Pregnancy and injecting drug use. BMJ 2008; 336: 1303-1305
  • 4 Substance Abuse and Mental Health Services Administration Results from the 2010 National Survey on Drug Use and Health: summary of national findings. NSDUH Series H-41, HHS Publication No. (SMA) 11-4658. Rockville (MD): SAHMSA; 2011. Internet: http://www.oas.samhsa.gov/NSDUH/2k10NSDUH/2k10Results.pdf
  • 5 Lester BM, ElSohly M, Wright LL et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics 2001; 107: 309-317
  • 6 Sanaullah F, Gillian M, Lavin T. Screening of substance misuse during early pregnancy in Blyth: an anonymous unlinked study. J Obstet ­Gynaecol. 2006; 26: 187-190
  • 7 Calvin C, Moriarty H. A special type of ‘hard-to-reach’ patient: experiences of pregnant women on methadone. J Prim Health Care 2010; 2: 61-69
  • 8 Bessa MA, Mitsuhiro SS, Chalem E et al. Underreporting of use of cocaine and marijuana during the third trimester of gestation among pregnant adolescents. Addict Behav. 2010; 35: 266-269
  • 9 Winklbaur B, Kopf N, Ebner N et al. Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates. Addiction 2008; 103: 1429-1440
  • 10 NICE-Guidelines. Pregnancy and Complex Social Factors . A model for service provision for pregnant women with complex social factors 2010; 110: 49-73 Internet http://www.nice.org.uk/nicemedia/live/13167/50861/50861.pdf
  • 11 Opioid Abuse, Dependence and Addiction in Pregnancy ACOG Committee Opinion Nr. 524, May 2012. Internet: https://www.acog.org/Resources_And_Publications/Committee_Opinions/Committee_on_Health_Care_for_Underserved_Women/Opioid_Abuse_Dependence_and_Addiction_in_Pregnancy#1
  • 12 Kästner R, Härtl K, Lieber A et al. Substitutionsbehandlung von opiat­abhängigen Schwangeren – Analyse der Behandlungsverläufe an der 1. UFK München. Geburts Frauenheilk 2002; 62 (Suppl 1): 32-36
  • 13 Norman RE, Byambaa M, De R et al. The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis. PLoS Med 2012; 9 e1001349. Published online 2012 November 27
  • 14 Velez ML, Montoya ID, Jansson LM et al. Exposure to violence among substance-dependent pregnant women and their children. J Subst Abuse Treat. Jan 2006; 30: 31-38
  • 15 Cavanaugh CE, Latimer WW. Recent sex trade and injection drug use among pregnant opiate and cocaine dependent women in treatment: The significance of psychiatric comorbidity. Addict Disord Ther Treat 2010; 9: 32-40
  • 16 Fenton MC, Keyes K, Geier T et al. Psychiatric comorbidity and the persistence of drug use disorders in the United States. Addiction. 2012; 107 599-609
  • 17 Rementeriá JL, Nunag NN. Narcotic withdrawal in pregnancy: Stillbirth incidence with a case report. Am J Obstet Gynecol. 1973; 116: 1152-1156
  • 18 Bart G. Maintenance medication for opiate addiction: the foundation of recovery. J Addict Dis 2012; 31: 207-25
  • 19 Jones HE, Finnegan LP, Kaltenbach K. Methadone and buprenorphine for the management of opioid dependence in pregnancy. Drugs 2012; 72: 747-57
  • 20 Jones HE, Kaltenbach K, Heil SH et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med 2010; 363: 2320-2331
  • 21 McCance-Katz EF. Drug interactions associated with methadone, buprenorphine, cocaine, and HIV medications: implications for pregnant women. Life Sci 2011; 88: 953-958
  • 22 Schmitz S, Poehlke T, Siedentopf J-P et al. Therapieempfehlungen zur Anwendung von Buprenorphin/Naloxon in der Substitutionsbehandlung von Patienten mit Opioidabhängigkeit 2013; 15: 190-201
  • 23 Konijnenberg C, Melinder A. Prenatal exposure to methadone and buprenorphine: a review of the potential effects on cognitive development. Child Neuropsychol 2011; 17: 495-519
  • 24 Lund IO, Fischer G, Welle-Strand GK et al. A Comparison of Buprenorphine+Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes. Subst Abuse 2013; 7: 61-74
  • 25 Newman RG, Gevertz SG. Comment on “A Comparison of Buprenorphine+Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes”. Subst Abuse 2013; 7: 107-108
  • 26 Jones HE, O’Grady KE, Malfi D et al. Methadone maintenance vs. methadone taper during pregnancy: maternal and neonatal outcomes. Am J Addict 2008; 17: 372-86
  • 27 Metz V, Köchl B, Fischer G. Should pregnant women with substance use disorders be maaged differently?. Neuropsychiatry (London) 2012; 2: 29-41
  • 28 Schmittner J, Schroeder JR, Epstein DH et al. Menstrual cycle length during methadone maintenance. Addiction 2005; 100: 829-836
  • 29 Sharpe TT, Velasquez MM. Risk of alcohol-exposed pregnancies among low-income, illicit drug-using women. J Womens Health (Larchmt) 2008; 17: 1339-1344
  • 30 Irner TB. Substance exposure in utero and developmental consequences in adolescence: a systematic review. Child Neuropsychol 2012; 18: 521-549
  • 31 Mactier H. Neonatal and longer term management following substance misuse in pregnancy. Early Hum Dev. 2013; 89: 887-92
  • 32 Spiteri Cornish K, Hrabovsky M, Scott NW et al. The short- and long-term effects on the visual system of children following exposure to maternal substance misuse in pregnancy. Am J Ophthalmol. 2013; 156: 190
  • 33 Europäische Beobachtungsstelle für Drogen und Drogensucht . Drogenangebot in Europa. In: Europäischer Drogenbericht 2013: Trends und Entwicklungen. Luxemburg: Amt für Veröffentlichungen der Europäischen Union; 2013: 28-29
  • 34 Hermanns-Clausen M, Kneisel S, Szabo B et al. Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings. Addiction 2013; 108: 534-544
  • 35 de Castro A, Jones HE, Johnson RE et al. Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes. Ther Drug Monit 2011; 33: 443-452
  • 36 Deutsche Hauptstelle für Suchtfragen e. V.. Du bist schwanger…und nimmst Drogen. Informationen und Hilfen für Drogen, Alkohol und Nikotin konsumierende Schwangere. Broschüre. 2012
  • 37 DGGG Ultraschalldiagnostik im Rahmen der Schwangerenvorsorge. AWMF 015/044 (S1)
  • 38 López M, Coll O. Chronic viral infections and invasive procedures: risk of vertical transmission and current recommendations. Fetal Diagn Ther. 2010; 28: 1-8
  • 39 Minkoff H, Zhong Y, Strickler HD et al. The relationship between cocaine use and human papillomavirus infections in HIV-seropositive and HIV-seronegative women. Infect Dis Obstet Gynecol; published online April 15 2008; 587082
  • 40 Wissenschaftliches Kuratorium der Deutschen Hauptstelle für Suchtfragen e.V . Drogenabhängigkeit 2006; Band 4: 54-5 ISBN: 3-937587-03-9
  • 41 Pinto SM, Dodd S, Walkinshaw SA et al. Substance abuse during pregnancy: effect on pregnancy outcomes. Eur J Obstet Gynecol Reprod Biol 2010; 150: 137-141
  • 42 DGGG . Standards in der Perinatalmedizin-Dopplersonografie in der Schwangerschaft. Geburtsh Frauenheilk 2003; 63: 21-25
  • 43 Kaltenbach K, Holbrook AM, Coyle MG et al. Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. Addiction 2012; 107 (Suppl 1): 45-42
  • 44 Winklbaur B, Baewert A, Jagsch R et al. Association between prenatal tobacco exposure and outcome of neonates born to opioid-maintained mother. Implications for treatment. Eur Addict Res 2009; 15: 150-156
  • 45 Heberlein A, Leggio L, Stichtenoth D et al. The treatment of alcohol and opioid dependence in pregnant women. Curr Opin Psychiatry 2012; 25: 559-564
  • 46 Ghamar Chehreh ME, Tabatabaei SV, Khazanehdari S et al. Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV- mothers: a meta-analysis. Arch Gynecol Obstet 2011; 283: 255-260
  • 47 Mehta V, Langford RM. Acute pain management for opioid dependent patients. Anästhesia 2006; 61: 269-276
  • 48 Jones HE, O’Grady K, Dahne J et al. Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. Am J Drug Alcohol Abuse 2009; 35: 151-156
  • 49 Kork F, Kleinwächter R, Kaufner L et al. Kreißende mit Substanzkonsum-Bedeutung in der geburtshilflichen Anästhesie. Anästhesiol Intensivmed Notfallmed Schmerzther 2011; 46: 640-646
  • 50 Höflich AS, Langer M, Jagsch R et al. Peripartum pain management in opioid dependent women. Eur J Pain Apr 2012; 16: 574-584
  • 51 Meyer M, Paranya G, Keefer Noris A et al. Intrapartum and postpartum analgesia for women maintained on buprenorphine during pregnancy. Eur J Pain. 2010; 14: 939-943
  • 52 Meyer M, Wagner K, Benvenuto A et al. Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. Obstet Gynecol 2007; 110: 261-266
  • 53 Begg EJ, Malpas TJ, Hackett LP et al. Distribution of R- and S-methadone into human milk during multiple, medium to high oral dosing. Br J Clin Pharmacol 2001; 52: 681-685
  • 54 Lindemalm S, Nydert P, Svensson JO et al. Transfer of buprenorphine into breast milk and calculation of infant drug dose. J Hum Lact 2009; 25: 199-205
  • 55 Jones HE, Heil SH, Baewert A et al. Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. Addiction 2012; 107 (Suppl 1): 5-27
  • 56 Kashiwagi M, Schäfer C, Kästner R et al. Opiatabhängigkeit und Stillen-Literaturübersicht und Empfehlungen. Geburtsh Frauenheilk 2005; 65: 938-941
  • 57 Stillen und Rauchen Aktualisierte Empfehlung der Nationalen Stillkommission, 2006. Internet: http://www.bfr.bund.de/cm/343/stillen_und_rauchen.pdf
  • 58 Laufs R, Polywka S. Risiko der Hepatitis-C-Übertragung durch Stillen. Dt. Ärztebl 2000; 97: A2462-A2463
  • 59 Hepatitis C und Stillen Zweite ergänzende Empfehlungen der Nationale Stillkommission vom 30. Mai 2008. Internet: http://www.bfr.bund.de/cm/343/hepatitis_c_und_stillen_zweite_ergaenzung.pdf
  • 60 Cleary BJ, Donnelly J, Strawbridge J et al. Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. Addiction 2010; 105: 2071-2084
  • 61 Chisolm MS, Acquavita SP, Kaltenbach K et al. Cigarette Smoking and Neonatal Outcomes in Depressed and Non-Depressed Opioid-Dependent Agonist-Maintained Pregnant Patients. Addict Disord Their Treat 2011; 10: 180-187
  • 62 Wachman EM, Hayes MJ, Brown MS et al. Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. JAMA 2013; 309: 1821-1827
  • 63 Keegan J, Parva M, Finnegan M et al. Addiction in pregnancy. J Addict Dis. 2010; 29: 175-191
  • 64 Ramsey SE, Bell KM, Engler-Field PA. HIV Risk Behavior Among Female Substance Abusers. J Addict Dis. 2010; 29: 192-199
  • 65 Heil SH, Jones HE, Arria A et al. Unintended Pregnancy in Opioid-abusing Women. J Subst Abuse Treat Mar 2011; 40 () 199-202
  • 66 Welle-Strand GK, Waal H, Bakstad B et al. Neonatal outcomes following in utero exposure to methadone or buprenorphine: A National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009. Drug Alcohol Depend. 2013 Jan 1, 127: 200-206.
  • 67 Holbrook AM, Kaltenbach KA. Effectiveness of a Smoking Cessation Intervention for Methadone-Maintained Women: A Comparison of Pregnant and Parenting Women. Int J Pediatr 2011; Published online 2011: 567056
  • 68 Massey SH, Liebermann DZ, Reiss D et al. Association of Clinical Characteristics and Cessation of Tobacco, Alcohol and Illicit Drug Use during Pregnancy. Am J Addict Mar 2011; 20: 143-150
  • 69 Delano K, Gareri J, Koren G. Rates of Fetal Polydrug Exposures in Methadone-Maintained Pregnancies from a High-Risk Population. PLoS One 2013; 8: e82647 Published online
  • 70 McCarthy JJ. Intrauterine abstinence syndrome (IAS) during buprenoprphine inductions and methadone tapers: can we assure the safety of the fetus?. J Matern Fetal Neonatal Med 2012; 25: 109-112
  • 71 Anstice S, Strike CJ, brands B. Supervised methadone consumption: client issues and stigma. Subst Use Misuse. 2009; 44: 794-808
  • 72 Morton J, Konrad SC. Introducing a caring/relational framework for building relationships with addicted mothers. J Obstet Gynecol Neonatal Nurs. 2009; 38: 206-213