Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle

Abstract

The synthesis of a new ‘eastern domain’ of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by ring-closing metathesis. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay.

Key words

total synthesis - natural products - olefin metathesis - relay ring-closing metathesis

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