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Synlett 2014; 25(15): 2166-2170
DOI: 10.1055/s-0034-1378532
DOI: 10.1055/s-0034-1378532
letter
Direct Synthesis of Polybenzylated Glutamic Acid Monoesters: Disambiguation of N,N-Dibenzylglutamic Acid α- and γ-Benzyl Esters
Further Information
Publication History
Received: 15 May 2014
Accepted after revision: 25 June 2014
Publication Date:
13 August 2014 (online)
Abstract
In this study, we explored the regioselective benzylation of l-glutamic acid under substoichiometric amounts of the alkylating agent. Our results demonstrate unambiguously that N,N-dibenzylglutamic acid γ-benzyl ester was not obtained by direct benzylation of l-glutamic acid as reported by other authors. Instead, under such reaction conditions N,N-dibenzylglutamic acid α-benzyl ester was obtained.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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