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Synlett 2014; 25(14): 1991-1996
DOI: 10.1055/s-0034-1378395
DOI: 10.1055/s-0034-1378395
letter
A Detour Route for meta Functionalization of Phenols
Further Information
Publication History
Received: 15 May 2014
Accepted after revision: 10 June 2014
Publication Date:
16 July 2014 (online)
Abstract
Cyclohexadienones participate in a two-step procedure, a Michael addition followed by aromatization, providing hitherto difficult-to-synthesize meta-functionalized phenol derivatives in good yield. Application of the developed approach is exemplified by synthesizing C-aryl acetophenones, C-aryl glycines, and elemicin – an allylphenol natural product.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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For reviews on cyclohexadienones, see:
For the synthetic protocols for the preparation of cyclohexadienones, see:
For the preparation and analytical data for compound 1, see:
For compound 6, see:
For compound 7 and 8, see: