Klinische Neurophysiologie 2014; 45(02): 106-112
DOI: 10.1055/s-0034-1372629
Originalia
© Georg Thieme Verlag KG Stuttgart · New York

Tiefe Hirnstimulation beim Tourette-Syndrom

Deep Brain Stimulation in Tourette Syndrome
T. Schüller
1   Klinik für Psychiatrie und Psychotherapie, Uniklinik Köln
,
D. Huys
1   Klinik für Psychiatrie und Psychotherapie, Uniklinik Köln
,
M. Blum
1   Klinik für Psychiatrie und Psychotherapie, Uniklinik Köln
,
D. Lenartz
2   Klinik für Stereotaxie und Neurochirurgie, Uniklinik Köln
,
E. Shubina
1   Klinik für Psychiatrie und Psychotherapie, Uniklinik Köln
,
V. Visser-Vandewalle
2   Klinik für Stereotaxie und Neurochirurgie, Uniklinik Köln
,
J. Kuhn
1   Klinik für Psychiatrie und Psychotherapie, Uniklinik Köln
› Author Affiliations
Further Information

Publication History

Publication Date:
01 July 2014 (online)

Zusammenfassung

Das bei Bewegungsstörungen etablierte Verfahren der tiefen Hirnstimulation (THS) wird auch hinsichtlich seines Nutzens zur Behandlung psychiatrischer Indikationen untersucht. Ziel dieser Arbeit ist es, einen Überblick über die Datenlage zur Anwendung der THS beim Tourette-Syndrom zu geben. Die Übersicht stützt sich dabei auf eine selektive stichwortgebundene Literaturrecherche in Pubmed unter Berücksichtigung einschlägiger Referenzen und eigener Arbeiten. Es zeigt sich, dass zur Behandlung des Tourette-Syndroms mittels THS Ergebnisse aus mehreren Studien vorliegen, die zwar nur kleine Fallzahlen umfassen, dabei aber deutliche Besserungsquoten hinsichtlich der Tic-Symptomatik aufzeigen.

Abstract

Deep brain stimulation (DBS) is an established treatment option for movement disorders which is also used in specific psychiatric disorders. Based on a selective keyword literature search (PubMed) and taking relevant references and our own investigations into account, the present manuscript reviews studies investigating DBS as a treatment option for Tourette syndrome. Until now, only studies with small sample sizes have been conducted. Nevertheless, the results seem to be promising.

 
  • Literatur

  • 1 Jankovic J, Kurlan R. Tourette syndrome: evolving concepts. Movement Disorders 2011; 26: 1149-1156
  • 2 Eddy CM, Cavanna AE. ‘It’s a curse!’: coprolalia in Tourette syndrome. European Journal of Neurology 2013; DOI:
  • 3 Cavanna A, Servo S, Monaco F et al. The behavioral spectrum of Gilles de la Tourette syndrome. The Journal of neuropsychiatry and clinical neurosciences 2009; 21: 13-23
  • 4 Cavanna AE, Critchley HD, Orth M et al. Dissecting the Gilles de la Tourette spectrum: a factor analytic study on 639 patients. Journal of Neurology, Neurosurgery & Psychiatry 2011; 82: 1320-1323
  • 5 Freeman RD, Zinner SH, Müller-Vahl KR et al. Coprophenomena in Tourette syndrome. Developmental Medicine & Child Neurology 2009; 51: 218-227
  • 6 Leckman JF. Tourette’s syndrome. The Lancet 2002; 360: 1577-1586
  • 7 Bloch MH, Peterson BS, Scahill L et al. Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Archives of pediatrics & adolescent medicine 2006; 160: 65
  • 8 Coffey BJ, Biederman J, Geller D et al. Reexamining tic persistence and tic-associated impairment in Tourette’s disorder: findings from a naturalistic follow-up study. The Journal of nervous and mental disease 2004; 192: 776-780
  • 9 Leckman JF, Zhang H, Vitale A et al. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics 1998; 102: 14-19
  • 10 Knight T, Steeves T, Day L et al. Prevalence of tic disorders: a systematic review and meta-analysis. Pediatric neurology 2012; 47: 77-90
  • 11 Müller N. Tourette’s syndrome: clinical features, pathophysiology, and therapeutic approaches. Dialogues in clinical neuroscience 2007; 9: 161
  • 12 Freeman RD, Fast DK, Burd L et al. An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries. Developmental Medicine & Child Neurology 2000; 42: 436-447
  • 13 Swain JE, Scahill L, Lombroso PJ et al. Tourette syndrome and tic disorders: a decade of progress. Journal of the American Academy of Child & Adolescent Psychiatry 2007; 46: 947-968
  • 14 Khalifa N, Knorring AL. Tourette syndrome and other tic disorders in a total population of children: clinical assessment and background. Acta paediatrica 2005; 94: 1608-1614
  • 15 Mathews CA, Jang KL, Herrera LD et al. Tic symptom profiles in subjects with Tourette syndrome from two genetically isolated populations. Biological psychiatry 2007; 61: 292-300
  • 16 Müller-Vahl K, Dodel I, Müller N et al. Health-related quality of life in patients with Gilles de la Tourette’s syndrome. Movement Disorders 2010; 25: 309-314
  • 17 Schrag A, Gilbert R, Giovannoni G et al. Streptococcal infection, Tourette syndrome, and OCD Is there a connection?. Neurology 2009; 73: 1256-1263
  • 18 Peterson BS, Thomas P, Kane MJ et al. Basal Ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry 2003; 60: 415-424
  • 19 Wang Z, Maia TV, Marsh R et al. The neural circuits that generate tics in Tourette’s syndrome. American Journal of Psychiatry 2011; 168: 1326-1337
  • 20 Cohen DJ. Tourette’s syndrome – tics, obsessions, compulsions: developmental psychopathology and clinical care. John Wiley & Sons; 1999
  • 21 Huys D, Hardenacke K, Poppe P et al. Update on the role of antipsychotics in the treatment of Tourette syndrome. Neuropsychiatric disease and treatment 2012; 8: 95
  • 22 Singer HS, Szymanski S, Giuliano J et al. Elevated intrasynaptic dopamine release in Tourette’s syndrome measured by PET. Am J Psychiatry 2002; 159: 1329-1336
  • 23 Wong DF, Brasic JR, Singer HS et al. Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology 2008; 33: 1239-1251
  • 24 Azrin N, Nunn R. Habit-reversal: a method of eliminating nervous habits and tics. Behaviour research and therapy 1973; 11: 619-628
  • 25 Wilhelm S, Deckersbach T, Coffey BJ et al. Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. American Journal of Psychiatry 2003; 160: 1175-1177
  • 26 Huys D, Möller M, Kim E-H et al. Die tiefe Hirnstimulation bei psychiatrischen Erkrankungen. Der Nervenarzt 2012; 83: 1156-1168
  • 27 Hassler R, Dieckmann G. Stereotaxic treatment of tics and inarticulate cries or coprolalia considered as motor obsessional phenomena in Gilles de la Tourette’s disease. Revue neurologique 1970; 123: 89
  • 28 Vandewalle V, van der Linden C, Groenewegen H et al. Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus. The Lancet 1999; 353: 724
  • 29 Müller-Vahl KR, Cath DC, Cavanna AE et al. European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. European child & adolescent psychiatry 2011; 20: 209-217
  • 30 Mink JW, Walkup J, Frey KA et al. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Movement Disorders 2006; 21: 1831-1838
  • 31 Dueck A, Wolters A, Wunsch K et al. Deep brain stimulation of globus pallidus internus in a 16-year-old boy with severe Tourette syndrome and mental retardation. Neuropediatrics 2009; 40: 239-242
  • 32 Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends in neurosciences 1990; 13: 266-271
  • 33 Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor,“prefrontal” and “limbic” functions. Progress in brain research 1991; 85: 119-146
  • 34 Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual review of neuroscience 1986; 9: 357-381
  • 35 Visser-Vandewalle V, Temel Y, Boon P et al. Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome: report of three cases. Journal of neurosurgery 2003; 99: 1094-1100
  • 36 Vernaleken I, Kuhn J, Lenartz D et al. Bithalamical deep brain stimulation in Tourette syndrome is associated with reduction in dopaminergic transmission. Biological psychiatry 2009; 66: e15-e17
  • 37 Kuhn J, Janouschek H, Raptis M et al. In Vivo Evidence of Deep Brain Stimulation-Induced Dopaminergic Modulation in Tourette’s Syndrome. Biological psychiatry 2012; 71: e11-e13
  • 38 Idris Z, Ghani ARI, Mar W et al. Intracerebral haematomas after deep brain stimulation surgery in a patient with Tourette syndrome and low factor XIIIA activity. Journal of Clinical Neuroscience 2010; 17: 1343-1344
  • 39 Servello D, Porta M, Sassi M et al. Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. Journal of Neurology, Neurosurgery & Psychiatry 2008; 79: 136-142
  • 40 Maciunas RJ, Maddux BN, Riley DE et al. Prospective randomized double-blind trial of bilateral thalamic deep brain stimulation in adults with Tourette syndrome. 2007; DOI:
  • 41 Bajwa RJ, de Lotbinière AJ, King RA et al. Deep brain stimulation in Tourette’s syndrome. Movement Disorders 2007; 22: 1346-1350
  • 42 Huys DB, Bartsch C, Köster P et al. Motor improvement and emotional stabilization in Tourette patients after Deep Brain Stimulation of the ventral anterior and ventrolateral motor part of the thalamus. Biological psychiatry 2013; submitted
  • 43 Kuhn J, Bartsch C, Lenartz D et al. Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome. Translational psychiatry 2011; 1: e52
  • 44 Van der Linden C, Colle H, Vandewalle V et al. Successful treatment of tics with bilateral internal pallidum (GPi) stimulation in a 27-year-old male patient with Gilles de la Tourette’s syndrome (GTS). In Movement Disorders. Wiley-Liss Div John Wiley & Sons Inc, 605 Third Ave; New York, NY 10158-0012 USA: 2002: S341-S341
  • 45 Diederich NJ, Kalteis K, Stamenkovic M et al. Efficient internal pallidal stimulation in Gilles de la Tourette syndrome: a case report. Movement Disorders 2005; 20: 1496-1499
  • 46 Gallagher CL, Garell PC, Montgomery EB. Hemi tics and deep brain stimulation. Neurology 2006; 66: E12-E12
  • 47 Shahed J, Poysky J, Kenney C et al. GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities. Neurology 2007; 68: 159-160
  • 48 Dehning S, Mehrkens JH, Müller N et al. Therapy-refractory tourette syndrome: Beneficial outcome with globus pallidus internus deep brain stimulation. Movement Disorders 2008; 23: 1300-1302
  • 49 Dehning S, Feddersen B, Cerovecki A et al. Globus pallidus internus-deep brain stimulation in Tourette’s syndrome: Can clinical symptoms predict response?. Movement Disorders 2011; 26: 2440-2441
  • 50 Martínez-Fernández R, Zrinzo L, Aviles-Olmos I et al. Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus. Movement Disorders 2011; 26: 1922-1930
  • 51 Houeto J, Karachi C, Mallet L et al. Tourette’s syndrome and deep brain stimulation. Journal of Neurology, Neurosurgery & Psychiatry 2005; 76: 992-995
  • 52 Cannon E, Silburn P, Coyne T et al. Deep brain stimulation of anteromedial globus pallidus interna for severe Tourette’s syndrome. American Journal of Psychiatry 2012; 169: 860-866
  • 53 Vilela Filho O, Ragazzo P, Souza J et al. Bilateral GPe-DBS for Tourette syndrome: a double-blind prospective controlled study of seven patients (Abstr.). In Abstract book of the ASSFN (American Society for Stereotactic and Functional Neurosurgery), 2010 biennial meeting Bridging the Future of Neurosurgery. New York: 2010
  • 54 Piedimonte F, Andreani JCM, Piedimonte L et al. Behavioral and motor improvement after deep brain stimulation of the globus pallidus externus in a case of Tourette’s syndrome. Neuromodulation: Technology at the Neural Interface 2013; 16: 55-58
  • 55 Groenewegen HJ, Trimble M. The ventral striatum as an interface between the limbic and motor systems. CNS spectrums 2007; 12: 887
  • 56 Flaherty AW, Williams ZM, Amirnovin R et al. Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery 2005; 57: E403
  • 57 Neuner I, Podoll K, Lenartz D et al. Deep brain stimulation in the nucleus accumbens for intractable Tourette’s syndrome: follow-up report of 36 months. Biological psychiatry 2009; 65: e5-e6
  • 58 Sturm V, Lenartz D, Koulousakis A et al. The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. J Chem Neuroanat 2003; 26: 293-299
  • 59 Huff W, Lenartz D, Schormann M et al. Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: Outcomes after one year. Clin Neurol Neurosurg 2010; 112: 137-143
  • 60 Kuhn J, Lenartz D, Mai JK et al. Deep brain stimulation of the nucleus accumbens and the internal capsule in therapeutically refractory Tourette-syndrome. J Neurol 2007; 254: 963-965
  • 61 Kuhn J, Lenartz D, Huff W et al. Transient Manic-like Episode Following Bilateral Deep Brain Stimulation of the Nucleus Accumbens and the Internal Capsule in a Patient With Tourette Syndrome. Neuromodulation 2008; 11: 128-131
  • 62 Zšbek M, Sobstyl M, Koziara H et al. Deep brain stimulation of the right nucleus accumbens in a patient with Tourette syndrome. Case report. Neurologia i neurochirurgia polska 2008; 42: 554-559
  • 63 Servello D, Sassi M, Brambilla A et al. De novo and rescue DBS leads for refractory Tourette syndrome patients with severe comorbid OCD: a multiple case report. Journal of neurology 2009; 256: 1533-1539
  • 64 Sachdev PS, Cannon E, Coyne TJ et al. Bilateral deep brain stimulation of the nucleus accumbens for comorbid obsessive compulsive disorder and Tourette’s syndrome. BMJ Case Reports 2012; 2012
  • 65 Burdick A, Foote KD, Goodman W et al. Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive-compulsive disorder. Neurocase 2010; 16: 321-330
  • 66 Servello D, Porta M, Sassi M et al. Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. J Neurol Neurosurg Psychiatry 2008; 79: 136-142
  • 67 Shahed J, Poysky J, Kenney C et al. GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities. Neurology 2007; 68: 159-160
  • 68 Welter ML, Mallet L, Houeto JL et al. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol 2008; 65: 952-957
  • 69 Martinez-Torres I, Hariz M, Zrinzo L et al. Improvement of tics after subthalamic nucleus deep brain stimulation. Neurology 2009; 72: 1787-1789
  • 70 Servello D, Sassi M, Gaeta M et al. Tourette syndrome (TS) bears a higher rate of inflammatory complications at the implanted hardware in deep brain stimulation (DBS). Acta neurochirurgica 2011; 153: 629-632
  • 71 Porta M, Brambilla A, Cavanna A et al. Thalamic deep brain stimulation for treatment-refractory Tourette syndrome Two-year outcome. Neurology 2009; 73: 1375-1380
  • 72 Ackermans L, Kuhn J, Neuner I et al. Surgery for Tourette syndrome. World Neurosurgery 2012;
  • 73 Ackermans L, Duits A, van der Linden C et al. Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome. Brain 2011; 134: 832-844
  • 74 Pullen S, Wall C, Lee K et al. Neuropsychiatric Outcome of an Adolescent Who Received Deep Brain Stimulation for Tourette’s Syndrome. Case reports in neurological medicine 2011; 2011
  • 75 Lee M, Au-Yeung M, Hung K et al. Deep brain stimulation in a Chinese Tourette’s syndrome patient. Hong Kong Med J 2011; 17: 147-150
  • 76 Savica R, Stead M, Mack KJ et al. Deep brain stimulation in tourette syndrome: a description of 3 patients with excellent outcome. In Mayo Clinic Proceedings. Elsevier; 2012: 59-62
  • 77 Kaido T, Otsuki T, Kaneko Y et al. Deep brain stimulation for Tourette syndrome: A prospective pilot study in Japan. Neuromodulation: Technology at the Neural Interface 2011; 14: 123-129
  • 78 Welter M-L, Mallet L, Houeto J-L et al. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Archives of Neurology 2008; 65: 952
  • 79 Foltynie T, Martinez-Torres I, Zrinzo L et al. Improvement in vocal & motor tics following DBS of motor GPi for Tourette syndrome, not accompanied by subjective improvement in quality of life – A case report. 2009
  • 80 Shields DC, Cheng ML, Flaherty AW et al. Microelectrode-guided deep brain stimulation for Tourette syndrome: within-subject comparison of different stimulation sites. Stereotactic and Functional Neurosurgery 2007; 86: 87-91