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Semin Respir Crit Care Med 2013; 34(04): 487-498
DOI: 10.1055/s-0033-1351119
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Treatment of Acute Lung Injury: Current and Emerging Pharmacological Therapies

Rob Mac Sweeney
1   Centre for Infection and Immunity, Queen's University Belfast, Northern Ireland, United Kingdom
,
Mark Griffiths
2   Royal Brompton Hospital, Imperial College London, London, England, United Kingdom
,
Danny McAuley
1   Centre for Infection and Immunity, Queen's University Belfast, Northern Ireland, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
11 August 2013 (online)

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Abstract

As a syndrome of injurious pulmonary inflammation resulting in deranged respiratory physiology, acute lung injury affords numerous potential therapeutic targets. Two main pharmacological treatment strategies have arisen—the attempted inhibition of excessive inflammation or the manipulation of the resulting physiological derangement causing respiratory failure. Additionally, such interventions may allow the delivery of less injurious mechanical ventilation. An emerging approach is the use of cell-based therapy, which, rather than inhibiting the inflammatory process, seeks to convert it from an injurious process to a reparative one. This review outlines previous, current, and emerging pharmacological therapies for acute lung injury.

Keywords

acute lung injury - acute respiratory distress syndrome - pharmacotherapy
 

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