Am J Perinatol 2014; 31(03): 203-208
DOI: 10.1055/s-0033-1343772
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Influence of Changes in the Evaluation of Neonatal Jaundice

Arieh Riskin
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
,
Keren Cohen
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
,
Amir Kugelman
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
,
Marta Abend-Weinger
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
,
Miri Hemo
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
,
David Bader
1   Department of Neonatology, Bnai Zion Medical Center, Rappaort Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
› Author Affiliations
Further Information

Publication History

16 January 2013

06 March 2013

Publication Date:
24 April 2013 (online)

Abstract

Objective To study the influence of policy changes in the evaluation of neonatal hyperbilirubinemia on discharge process from the nursery. Changes included early assessment of risk factors by universal umbilical blood sampling for blood type, Coombs test, and glucose-6-phosphate dehydrogenase (G6PD) and universal noninvasive transcutaneous bilirubinometry at discharge.

Study Design The 1,569 newborns (≥ 36 weeks' gestation) admitted after the implementation of changes were compared with the 1,822 born before.

Results Policy changes improved the diagnosis of G6PD deficiency and ABO incompatibility and decreased the number of referrals from the community for jaundice follow-up. The average number of needlesticks per baby as well as the time required for the analysis of serum bilirubin levels on discharge day decreased. Changes did not significantly increase costs.

Conclusion Changes seem to have improved the quality of medical care, including early identification of risk factors and better follow-up of neonatal hyperbilirubinemia with reduction of pain and increased efficiency.

 
  • References

  • 1 American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004; 114: 297-316
  • 2 Keren R, Luan X, Friedman S, Saddlemire S, Cnaan A, Bhutani VK. A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants. Pediatrics 2008; 121: e170-e179
  • 3 Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med 2008; 358: 920-928
  • 4 Kuzniewicz MW, Escobar GJ, Newman TB. Impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use. Pediatrics 2009; 124: 1031-1039
  • 5 AAP Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics 2001; 108: 763-765
  • 6 Ip S, Lau J, Chung M , et al. Hyperbilirubinemia and kernicterus: 50 years later. Pediatrics 2004; 114: 263-264
  • 7 Maisels MJ, Newman TB. Kernicterus in otherwise healthy, breast-fed term newborns. Pediatrics 1995; 96 (4 Pt 1) 730-733
  • 8 Gupta P, Malhotra S, Singh DK, Dua T. Length of postnatal stay in healthy newborns and re-hospitalization following their early discharge. Indian J Pediatr 2006; 73: 897-900
  • 9 Kaplan M, Bromiker R, Schimmel MS, Algur N, Hammerman C. Evaluation of discharge management in the prediction of hyperbilirubinemia: the Jerusalem experience. J Pediatr 2007; 150: 412-417
  • 10 Kaplan M, Merlob P, Regev R. Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus. J Perinatol 2008; 28: 389-397
  • 11 Newman TB, Escobar GJ, Gonzales VM, Armstrong MA, Gardner MN, Folck BF. Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization. Pediatrics 1999; 104 (5 Pt 2) 1198-1203
  • 12 Newman TB, Liljestrand P, Escobar GJ. Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med 2005; 159: 113-119
  • 13 Grohmann K, Roser M, Rolinski B , et al. Bilirubin measurement for neonates: comparison of 9 frequently used methods. Pediatrics 2006; 117: 1174-1183
  • 14 Eggert LD, Wiedmeier SE, Wilson J, Christensen RD. The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system. Pediatrics 2006; 117: e855-e862
  • 15 Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C, Johnson LH. Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia. Pediatrics 2000; 106: E17
  • 16 Maisels MJ, Ostrea Jr EM, Touch S , et al. Evaluation of a new transcutaneous bilirubinometer. Pediatrics 2004; 113: 1628-1635
  • 17 Maisels MJ, Kring E. Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation. Pediatrics 2006; 117: 1169-1173
  • 18 Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 1999; 103: 6-14
  • 19 Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF. Hyperbilirubinemia in the newborn infant > or =35 weeks' gestation: an update with clarifications. Pediatrics 2009; 124: 1193-1198
  • 20 Kaplan M, Shchors I, Algur N, Bromiker R, Schimmel MS, Hammerman C. Visual screening versus transcutaneous bilirubinometry for predischarge jaundice assessment. Acta Paediatr 2008; 97: 759-763
  • 21 Riskin A, Tamir A, Kugelman A, Hemo M, Bader D. Is visual assessment of jaundice reliable as a screening tool to detect significant neonatal hyperbilirubinemia?. J Pediatr 2008; 152: 782-787 , e1–e2
  • 22 Yaseen H, Khalaf M, Rashid N, Darwich M. Does prophylactic phototherapy prevent hyperbilirubinemia in neonates with ABO incompatibility and positive Coombs' test?. J Perinatol 2005; 25: 590-594
  • 23 Kaplan M, Hammerman C. Glucose-6-phosphate dehydrogenase deficiency: a potential source of severe neonatal hyperbilirubinaemia and kernicterus. Semin Neonatol 2002; 7: 121-128
  • 24 Kaplan M, Hammerman C. Glucose-6-phosphate dehydrogenase deficiency: a hidden risk for kernicterus. Semin Perinatol 2004; 28: 356-364
  • 25 Kaplan M, Leiter C, Hammerman C, Rudensky B. Enzymatic activity in glucose-6-phosphate dehydrogenase-normal and -deficient neonates measured with a commercial kit. Clin Chem 1995; 41: 1665-1667
  • 26 Reclos GJ, Hatzidakis CJ, Schulpis KH. Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening. J Med Screen 2000; 7: 46-51
  • 27 Reclos GJ, Schulpis KH, Gavrili S, Vlachos G. Evaluation of glucose-6-phosphate dehydrogenase activity in two different ethnic groups using a kit employing the haemoglobin normalization procedure. Clin Biochem 2003; 36: 393-395
  • 28 WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ 1989; 67: 601-611
  • 29 Iranpour R, Hashemipour M, Talaei SM, Soroshnia M, Amini A. Newborn screening for glucose-6-phosphate dehydrogenase deficiency in Isfahan, Iran: a quantitative assay. J Med Screen 2008; 15: 62-64
  • 30 Watchko JF. Identification of neonates at risk for hazardous hyperbilirubinemia: emerging clinical insights. Pediatr Clin North Am 2009; 56: 671-687
  • 31 Bellieni CV, Iantorno L, Perrone S , et al. Even routine painful procedures can be harmful for the newborn. Pain 2009; 147: 128-131
  • 32 Ozawa M, Kanda K, Hirata M, Kusakawa I, Suzuki C. Influence of repeated painful procedures on prefrontal cortical pain responses in newborns. Acta Paediatr 2011; 100: 198-203
  • 33 Weissman A, Aranovitch M, Blazer S, Zimmer EZ. Heel-lancing in newborns: behavioral and spectral analysis assessment of pain control methods. Pediatrics 2009; 124: e921-e926
  • 34 Gartner LM, Morton J, Lawrence RA , et al; American Academy of Pediatrics Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2005; 115: 496-506
  • 35 Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. Cochrane Database Syst Rev 2007; (4) CD001452