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Synthesis 2014; 46(08): 1079-1084
DOI: 10.1055/s-0033-1338592
DOI: 10.1055/s-0033-1338592
paper
Staudinger Condensation for the Preparation of Thiohydantoins
Further Information
Publication History
Received: 28 November 2013
Accepted after revision: 10 January 2014
Publication Date:
24 February 2014 (online)
Abstract
An efficient one-pot, two-step sequence starting from azide derivatives is described: first, formation of iminophosphoranes (Staudinger reaction) and condensation with carbon disulfide to form nonisolated isothiocyanates; then, condensation with α-amino esters to provide new N-3-substituted 2-thiohydantoins.
Key words
heterocycles - aza-Wittig reaction - Staudinger condensation - amino acids - thiohydantoinsSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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