Download PDF
Zeitschrift für Phytotherapie 2013; 34(01): 06-11
DOI: 10.1055/s-0032-1331479
Übersicht
Typ-2-Diabetes
© Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Phytotherapeutische Optionen bei Diabetes mellitus Typ 2

Karin Kraft
Subject Editor:
Further Information

Publication History

Publication Date:
28 March 2013 (online)

    Permissions and Reprints

Zusammenfassung

Diabetes mellitus Typ 2 nimmt weltweit zu. Aufgrund der noch immer nicht ganz zufriedenstellenden medikamentösen Standardtherapie und ihrer hohen Kosten ist die intensive Suche nach weiteren Wirkprinzipien und Wirkstoffen gerechtfertigt. Der Artikel gibt einen Überblick über bekannte Wirkprinzipien von in diesem Indikationsbereich verwendeten pflanzlichen Drogen und über die Situation hinsichtlich klinischer Studien. Die Erkenntnisse sind großenteils noch lückenhaft. Ballaststoffhaltige Dogen, insbesondere Flohsamen, scheinen sich zumindest zur adjuvanten Therapie gut zu eignen. Das präventive Potenzial mancher Drogen beim Typ-2-Diabetes wird vermutlich bisher unterschätzt. Weitere Untersuchungen sind aufgrund der allgemein guten Verträglichkeit der bisher identifizierten pflanzlichen Drogen unbedingt zu empfehlen.

Summary

Phytotherapeutic options for diabetes mellitus type 2

The prevalence of diabetes mellitus type 2 is increasing worldwide. However, standard oral antidiabetic drugs are still not completely convincing, and also are rather expensive. This justifies the present intensive search for further substances. The article gives an overview of the pharmacological effects of herbal drugs such as cinnamon or bitter cucumber as well as the current state of the respective clinical trials. Although the findings are largely incomplete, fibre-containing remedies, particularly psyllium, are apparently suitable at least for adjuvant therapy. Also the preventive potential of some herbal drugs seems to be largely underestimated. Further studies are recommended due to the good tolerability of the hitherto identified phytotherapeutic remedies.

Schlüsselwörter

Diabetes mellitus Typ 2 - klinische Studien - Ballaststoffe - Zimtrinde - Bittergurke

Key words

Diabetes mellitus type 2 - clinical trials - fiber - cinnamon - bitter cucumber
 

  • Literatur

  • 1 Danaei G, Finucane MM, Lu Y et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011; 378 (9785) 31-40
    CrossrefPubMedGoogle Scholar
  • 2 Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998 352. (9131) 837-853
    PubMed
  • 3 Roumie CL, Hung AM, Greevy RA et al. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study. Ann Intern Med. 2012; 157: 601-610
    PubMedGoogle Scholar
  • 4 Jenkins DJ, Kendall CW, Augustin LS, Vuksan V. High-complex carbohydrate or lente carbohydrate foods?. Am J Med 2002; 113 (Suppl. 9B) 30S-37S
    PubMedGoogle Scholar
  • 5 Ziai SA, Larijani B, Akhoondzadeh S et al. Psyllium decreased serum glucoseand glycosylated hemoglobin significantlyin diabetic outpatients. J Ethnopharmacol 2005; 102: 202-207
    CrossrefPubMedGoogle Scholar
  • 6 Butt MS, Shahzadi N, Sharif MK, Nasir M. Guar gum: a miracle therapy for hypercholesterolemia, hyperglycemia and obesity. Crit Rev Food Sci Nutr 2007; 47: 389-396
    CrossrefPubMedGoogle Scholar
  • 7 Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus.. J Diet Suppl 2011; 8: 257-265
    CrossrefPubMedGoogle Scholar
  • 8 Kannappan S, Jayaraman T, Rajasekar P et al. Cinnamon bark extract improves glucose metabolism and lipid profile in the fructosefed rat. Singapore Med J 2006; 47: 858-863
    PubMedGoogle Scholar
  • 9 Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose In db/db mice.. J Ethnopharmacol 2006; 104: 119-123
    CrossrefPubMedGoogle Scholar
  • 10 Subash BabuP, Prabuseenivasan S, Ignacimuthu S Cinnamaldehyde - a potential antidiabetic agent. Phytomedicine 2007; 14: 15-22
    PubMed
  • 11 Roffey B, Atwal A, Kubow S. Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.. Mol Nutr Food Res 2006; 50: 739-745
    CrossrefPubMedGoogle Scholar
  • 12 Leach MJ, Kumar S. Cinnamon for diabetes mellitus.. Cochrane Database Syst Rev 2012; 9: CD007170
    PubMedGoogle Scholar
  • 13 Ma J, Whittaker P, Keller AC et al. Cucurbitane-type triterpenoids from Momordica charantia . Planta Med 2010; 76: 1758-1761
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Tan MJ, Ye JM, Turner N et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 2008; 15: 263-273
    CrossrefPubMedGoogle Scholar
  • 15 Bielenberg J. Die blutzuckersenkende und fettabbauende Aktivität der Bittermelone. Z Phytother 2012; 33: 215-220
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Ooi CP, Yassin Z, Hamid TA. Momordica charantia for type 2 diabetes mellitus.. Cochrane Database Syst Rev 2012; 8: CD007845
    PubMedGoogle Scholar
  • 17 Melzig MF, Funke I. [Inhibitors of alpha-amy-lase from plants - a possibility to treat diabetes mellitus type II by phytotherapy?]. Wien Med Wochenschr 2007; 157: 320-324
    CrossrefPubMedGoogle Scholar
  • 18 Shinde J, Taldone T, Barletta M et al. Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats. Carbohydr Res 2008; 343: 1278-1281
    CrossrefPubMedGoogle Scholar
  • 19 Karthic K, Kirthiram KS, Sadasivam S, Thayumanavan B. Identification of alpha amylase inhibitors from Syzygium cumini Linn seeds. Indian J Exp Biol 2008 46. 677-680
    PubMedGoogle Scholar
  • 20 Weidner C, de Groot JC, Prasad A. et al. Amorfrutins are potent antidiabetic dietary natural products. Proc Natl Acad Sci USA 2012; 109: 7257-7262
    CrossrefPubMedGoogle Scholar
  • 21 de Groot JC, Weidner C, Krausze J. et al. Structural characterization ofamorfrutins bound to the peroxisome proliferator-activated receptor gamma. J Med Chem 2013; DOI: 10.1021/jm3013272
    PubMedGoogle Scholar
  • 22 Wainstein J, Ganz T, Boaz M et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012; 15: 605-610
    CrossrefPubMedGoogle Scholar
  • 23 Ashraf R, Khan RA, Ashraf IGarlic. (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci 2011 24. 565-570
    PubMedGoogle Scholar
  • 24 Bamosa AO, Kaatabi H, Lebdaa FM et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010; 54: 344-354
    PubMedGoogle Scholar
  • 25 Kim S, Shin BC, Lee MS et al. Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials. Chin J Integr Med 2011; 17: 937-944
    CrossrefPubMedGoogle Scholar
  • 26 Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R et al. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012; 35: 2121-2127
    CrossrefPubMedGoogle Scholar