Download PDF
ZWR - Das Deutsche Zahnärzteblatt 2012; 121(9): 418-423
DOI: 10.1055/s-0032-1329573
Fortbildung
Neue Technologien
© Georg Thieme Verlag Stuttgart · New York

Stammzellbasierte Zahnregeneration im Tiermodell

M Steindorff
1   Medizinische Hochschule Hannover
,
H Lehl
1   Medizinische Hochschule Hannover
,
A Winkel
1   Medizinische Hochschule Hannover
,
M Stiesch
1   Medizinische Hochschule Hannover
› Author Affiliations
Further Information

Publication History

Publication Date:
30 October 2012 (online)

Also available at
    Permissions and Reprints

Im Bereich der dentalen Stammzellforschung gibt es seit einigen Jahren vielversprechende Ansätze, natürliche Zähne mithilfe stammzellbasierter Gewebe- sowie Zahnhartsubstanz-Regenerationen wiederherzustellen. Dabei wird meist ein Trägermaterial (Scaffold) eingesetzt, das mit Stammzellen besiedelt und anschließend ins Tier implantiert wird. Zahnähnliche Strukturen konnten vielfach erzeugt werden, doch bleibt bis zur medizinischen Anwendung noch erheblicher Forschungsbedarf bestehen.

 

  • Literatur

  • 1 Akizuki T, Oda S, Komaki M et al. Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs. J Periodontal Res 2005; 40: 245-251
    CrossrefPubMedGoogle Scholar
  • 2 Andersen AC. The Beagle as an Experimental Dog. Ames: Iowa State University Press; 1970
    Google Scholar
  • 3 Arakaki M, Ishikawa M, Nakamura T et al. Role of epithelial-stem cell interactions during dental cell differentiation. J Biol Chem 2012; 287: 10590-10601
    CrossrefPubMedGoogle Scholar
  • 4 Dangaria SJ, Ito Y, Luan X et al. Successful Periodontal Ligament Regeneration by Periodontal Progenitor Preseeding on Natural Tooth Root Surfaces. Stem Cells Dev 2011; 20: 1659-1668
    CrossrefPubMedGoogle Scholar
  • 5 Duailibi SE, Duailibi MT, Zhang W et al. Bioengineered Dental Tissues Grown in the Rat Jaw. J Dent Res 2008; 87: 745-750
    CrossrefPubMedGoogle Scholar
  • 6 El-Backly RM, Massoud AG, El-Badry AM et al. Regeneration of dentine/pulp-like tissue using a dental pulp stem cell/poly(lactic-co-glycolic) acid scaffold construct in New Zealand white rabbits. Aust Endod J 2008; 34: 52-67
    CrossrefPubMedGoogle Scholar
  • 7 Galler KM, Cavender AC, Koeklue U et al. Bioengineering of dental stem cells in a PEGylated fibrin gel. Regen Med 2011; 6: 191-200
    CrossrefPubMedGoogle Scholar
  • 8 Gronthos S, Brahim J, Li W et al. Stem cell properties of human dental pulp stem cells. J Dent Res 2002; 81: 531-535
    CrossrefPubMedGoogle Scholar
  • 9 Gronthos S, Mankani M, Brahim J et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci 2000; 97: 13625-13630
    CrossrefPubMedGoogle Scholar
  • 10 Guo W, He Y, Zhang X et al. The use of dentin matrix scaffold and dental follicle cells for dentin regeneration. Biomaterials 2009; 30: 6708-6723
    CrossrefPubMedGoogle Scholar
  • 11 Harada H, Mitsuyasu T, Toyono T et al. Epithelial stem cells in teeth. Odontology 2002; 90: 1-6
    CrossrefPubMedGoogle Scholar
  • 12 Ikeda E, Morita R, Nakao K et al. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci 2009; 106: 13475-13480
    CrossrefPubMedGoogle Scholar
  • 13 Kuo T-F, Lin H-C, Yang K-C et al. Bone Marrow Combined With Dental Bud Cells Promotes Tooth Regeneration in Miniature Pig Model. Artif Organs 2011; 35: 113-121
    PubMedGoogle Scholar
  • 14 Lang NP, Bragger U, Walther D et al. Ligature-induced peri-implant infection in cynomolgus monkeys. I. Clinical and radiographic findings. Clin Oral Implants Res 1993; 4: 2-11
    CrossrefPubMedGoogle Scholar
  • 15 Lee J-H, Lee D-S, Choung H-W et al. Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors. Biomaterials 2011; 32: 9696-9706
    CrossrefPubMedGoogle Scholar
  • 16 Li R, Guo W, Yang B et al. Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration. Biomaterials 2011; 32: 4525-4538
    CrossrefPubMedGoogle Scholar
  • 17 Lindhe J, Berglundh T, Ericsson I et al. Experimental breakdown of peri-implant and periodontal tissues. A study in the beagle dog. Clin Oral Implants Res 1992; 3: 9-16
    CrossrefPubMedGoogle Scholar
  • 18 Miura M, Gronthos S, Zhao M et al. SHED: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci 2003; 100: 5807-5812
    CrossrefPubMedGoogle Scholar
  • 19 Morotomi T, Kawano S, Toyono T et al. In vitro differentiation of dental epithelial progenitor cells through epithelial-mesenchymal interactions. Arch Oral Biol 2005; 50: 695-705
    CrossrefPubMedGoogle Scholar
  • 20 Muschler G, Nakamoto C, Griffith L. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 2004; 86: 1541-1558
    PubMedGoogle Scholar
  • 21 Novosel EC, Kleinhans C, Kluger PJ. Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev 2011; 63: 300-311
    CrossrefPubMedGoogle Scholar
  • 22 Ohazama A, Modino SAC, Miletich I et al. Stem-cell-based Tissue Engineering of Murine Teeth. J Dent Res 2004; 83: 518-522
    CrossrefPubMedGoogle Scholar
  • 23 Seo B-M, Miura M, Gronthos S et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. The Lancet 2004; 364: 149-155
    CrossrefPubMedGoogle Scholar
  • 24 Sonoyama W, Liu Y, Fang D et al. Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. PLoS ONE 2006; 1
    PubMedGoogle Scholar
  • 25 Steible JI. Der Hund als Tiermodell in der Parodontologie am Beispiel der rekonstruktiven Parodontitistherapie. [Dissertation]. TiHo Hannover 2001;
    PubMedGoogle Scholar
  • 26 Ulmer FL, Winkel A, Kohorst P et al. Stem cells - Prospects in dentistry. Schweiz Monatsschr zahnmed 2010; 120: 860-872
    PubMedGoogle Scholar
  • 27 Wang S, Liu Y, Fang D et al. The miniature pig: a useful large animal model for dental and orofacial research. Oral Dis 2007; 13: 530-537
    CrossrefPubMedGoogle Scholar
  • 28 Yang X, Walboomers XF, van den Beucken JJJP et al. Hard Tissue Formation of STRO-1-Selected Rat Dental Pulp Stem Cells In Vivo. Tissue Eng Part A 2008; 15: 367-375
    PubMedGoogle Scholar
  • 29 Young CS, Terada S, Vacanti JP et al. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res 2002; 81: 695-700
    CrossrefPubMedGoogle Scholar
  • 30 Yu J, Wang Y, Deng Z et al. Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. Biol Cell 2007; 99: 465-474
    CrossrefPubMedGoogle Scholar
  • 31 Zhang W, Ahluwalia IP, Yelick PC. Three dimensional dental epithelial-mesenchymal constructs of predetermined size and shape for tooth regeneration. Biomaterials 2010; 31: 7995-8003
    CrossrefPubMedGoogle Scholar