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Planta Med 2013; 79(06): 487-491
DOI: 10.1055/s-0032-1328297
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Flavonoids and 3-Arylcoumarin from Pterocarpus soyauxii

Zushang Su
1   National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX, USA
,
Ping Wang
1   National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX, USA
,
Wei Yuan
1   National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX, USA
,
Shiyou Li
1   National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX, USA
› Author Affiliations
Further Information

Publication History

received 27 November 2012
revised 30 January 2013

accepted 05 February 2013

Publication Date:
11 March 2013 (online)

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Abstract

Phytochemical study on the constituents of the heartwood of Pterocarpus soyauxii led to the isolation of five new isoflavonoids and one new 3-arylcoumarin, pterosonins A–F (1–6), together with 17 known analogues, among which 8, 9, and 18 were reported as natural products for the first time. Structure elucidation was achieved by way of spectroscopic measurements as well as by comparison with literature data. Only Compound 6 showed potent cytotoxicity against human non-small cell lung cancer (A549), pancreatic cancer (Panc-28), and colon carcinoma (HCT-116) cells with GI50 values at 7.39, 25, and 19.17 µM, respectively; the other isolates showed no cytotoxicity against the above tested cell lines with GI50 values > 50 µM.

Key words

Pterocarpus soyauxii - Fabaceae - padauk - flavonoid - pterosonics A–F - cytotoxicity

Supporting Information

 

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