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Horm Metab Res 2012; 44(09): 699-703
DOI: 10.1055/s-0032-1311606
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

A Change of Osteocalcin (OC) and Tartrate Resistant Acid Phosphatase 5b (TRACP-5b) with the Menstrual Cycle

S. Lee
1   Department of Physical Therapy, Aomori University of Health and Welfare, Aomori-shi, Aomori, Japan
,
T. Kumagai
2   Department of Nutrition, Aomori University of Health and Welfare, Aomori-shi, Aomori, Japan
,
J. Hashimoto
1   Department of Physical Therapy, Aomori University of Health and Welfare, Aomori-shi, Aomori, Japan
,
A. Satoh
3   Department of Nursing, Akita University of Nursing and Welfare, Odate-shi, Akita, Japan
,
T. Suzuki
1   Department of Physical Therapy, Aomori University of Health and Welfare, Aomori-shi, Aomori, Japan
,
K. Yamai
4   Department of Internal Medicine, Mutsu General Hospital, Mutsu-shi, Aomori, Japan
,
S. Ohta
5   Department of Obstetrics and Gynecology, Aomori Khosei Hospital, Aomori-shi, Aomori, Japan
› Author Affiliations
Further Information

Publication History

received 30 January 2012

accepted 29 March 2012

Publication Date:
19 April 2012 (online)

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Abstract

Bone metabolism markers associated with 4 menstrual cycle phases were evaluated in 14 healthy young females without menstrual disorder. Menstrual cycle phases were confirmed with basal body temperature for 3 months, luteinizing hormone kits, and sexual hormone concentrations of serum. The bone metabolism markers used were osteocalcin (OC), which was measured by immunoradiometric assay (IRMA), and tartrate resistant acid phosphatase 5b (TRACP-5b), which was measured by enzyme immunometric assay (EIA). The highest values of OC and TRACP-5b were observed in the ovulation phase, and TRACP-5b increased significantly when compared with levels in the menstrual phase (p<0.05). Furthermore, the changes in sex-hormone secretion involved in OC and TRACP-5b showed specific patterns during the menstrual cycle. In other words, TRACP-5b levels are influenced by sex hormones produced during the menstrual period and are based on the bone-formation status. Therefore, it is presumed that the TRACP-5b levels during ovulation play a central role in bone formation and bone metabolism.

Key words

menstrual cycle - sex hormone - ovulatory phase - osteocalcin - TRACP-5b
 

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