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Arzneimittelforschung 2001; 51(1): 67-71
DOI: 10.1055/s-0031-1300004
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Antimicrobial Activity of New Coumarin Derivatives

Masami Kawase
a   Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
,
Bharat Varu
b   Department of Chemistry, Saurashtra University, Rajkot, India
,
Anamik Shah
b   Department of Chemistry, Saurashtra University, Rajkot, India
,
Noboru Motohashi
c   Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
,
Satoru Tani
a   Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
,
Setsuo Saito
a   Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
,
Sanchayita Debnath
d   Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
,
S. Mahapatra
d   Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
,
Sujata G. Dastidar
d   Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
,
A. N. Chakrabarty
e   Department of Medical Microbiology and Parasitology, Calcutta University College of Medicine, Calcutta, India
› Author Affiliations
Further Information

Publication History

Publication Date:
27 December 2011 (online)

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Summary

A preliminary exploration of coumarin analogs as novel antimicrobial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The substituents ester or carboxylic acid on the coumarin ring were needed to have potent inhibitory activity against both Gram positive and Gram negative bacteria. The presence of phenolic hydroxyl group and/or carboxylic acid was necessary to possess higher activity against Helicobacter pylori.

Zusammenfassung

Antimikrobielle Aktivität neuer Coumarin Derivate

Eine vorläufige Untersuchung von Coumarin Analoga als neue antimikrobielle Wirkstoffe wurde durchgeführt, um die für die beobachtete biologische Aktivität verantwortlichen grundlegenden Strukturmerkmale zu bestimmen. Für eine starke hemmende Aktivität gegenGram positive und Gram negative Bakterien waren als Substituenten ein Ester oder eine Carbonsäure am Couma rin Ring erforderlich. Die Anwesenheit einer phenolischen Hydroxyl Gruppe und/oder einer Carbonsäure war Voraus Setzung für eine höhere Aktivität gegen Helicobacter pylori.

Key words

Coumarin derivatives, anti-Helicobacter pylori activity, antimicrobial activity - in vitro studies, synthesis