Download PDF
Arzneimittelforschung 2003; 53(5): 372-377
DOI: 10.1055/s-0031-1297122
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Analysis of the Urinary Excretion of Ifosfamide and its N-Dechloroethylated Metabolites in Children Using 31P-NMR Spectroscopy

Konrad Misiura
a   Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Ło´ dz´, Poland
,
Małgorzata Zubowska
b   Clinic of Pediatrics, Medical University of Ło´ dz´, Ło´ dz´, Poland
,
Elżbieta Zielińska
b   Clinic of Pediatrics, Medical University of Ło´ dz´, Ło´ dz´, Poland
› Author Affiliations
Further Information

Publication History

Publication Date:
25 December 2011 (online)

  PDF Download  Permissions and Reprints

Summary

Amounts of ifosfamide (CAS 3778-73-2) and its N-dechloroethylated metabolites excreted in the urine were measured using 31P-NMR spectroscopy in 26 cancer children treated with this drug. Strong inter-patient variation in levels of these compounds were found. These differences were independent from patients age, body surface area, and sex, the dose of the drug, suggesting genetic base of observed variations in ifosfamide metabolism.

Zusammenfassung

31Ifosfamid (CAS 3778-73-2) und seine Deschlorethyl-Metaboliten wurden im Harn krebskranker Kinder mit unterschiedlich lokalisierten Neoplasmen mittels 31P-NMR-spektroskopischer Analytik bestimmt. Es konnten erhebliche interindividuelle Unterschiede der Konzentrationen festgestellt werden, die unabhängig waren von Alter, Körperoberfläche, Geschlecht und Dosierung. Daher werden genetische Faktoren als Ursache für die festgestellten Abweichungen vermutet.

Key words

Anticancer drug - CAS 3778-73-2 - Ifosfamide, N-dechloroethylated metabolites, urinary excretion in children