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Arzneimittelforschung 2007; 57(9): 616-622
DOI: 10.1055/s-0031-1296657
Analgesics · Anti-inflammatories · Antiphlogistics · Antirheumatic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Evaluation of the Anti-inflammatory Activity of N-[2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-nicotinamide

Rajiv Kalia
1   Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, India
,
Chamallamudi Mallikarjuna Rao
1   Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, India
,
Nampurath Gopalan Kutty
1   Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, India
› Author Affiliations
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Publication History

Publication Date:
21 December 2011 (online)

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Abstract

A new molecule incorporating nicotinoyl moiety, thiazolidin-4-one ring and 3,5-di-tert-butyl-4-hydroxyphenyl group (a potent antioxidant moiety) was synthesized and evaluated for anti-inflammatory activity in acute as well as chronic phase models of inflammation. The compound exhibited significant anti-inflammatory activity in three experimental models of inflammation, comparable to the positive control drug, ibuprofen (CAS 15687-27-1). It is suggested that besides the hy-polipidemic and anti-oxidant potential of the molecule, its anti-inflammatory action could possibly act as an additional mechanism of its hypothesized anti-atherosclerotic activity.

Key words

Anti-atherosclerotic drugs - Anti-inflammatory drugs - Anti-oxidants - N-[2(3,5-Di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazo-lidin-3-yl]-nicotinamide - Nicotinic acid derivative - Thiazolidin-4-ones