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Arzneimittelforschung 2008; 58(10): 510-514
DOI: 10.1055/s-0031-1296550
Analgesics · Anti-inflammatories · Antiphlogistics · Antirheumatic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Synthesis, Characterization and Anti-inflammatory Activity of New 5-(3,4-Dichlorophenyl)-2-(aroylmethyl) thio-1,3,4-oxadiaxoles

Meric Koksal
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey
,
S Sirri Bilge
2   Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
,
Ayhan Bozkurt
3   Department of Physiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
,
Z Sibel Sahin
4   Department of Physics, Faculty of Arts and Sciences, Ondokuz Mayis University, Samsun, Turkey
,
Samil Isik
4   Department of Physics, Faculty of Arts and Sciences, Ondokuz Mayis University, Samsun, Turkey
,
Dilek Demir Erol
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
19 December 2011 (online)

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Abstract

Several 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. In addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug Indometacin (CAS 53-86-1).

Key words

■ 1,3,4-Oxadiazoles, anti-inflammatory activity, S-alkylation, synthesis, X-ray crystallography
 

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