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Arzneimittelforschung 2010; 60(10): 593-598
DOI: 10.1055/s-0031-1296331
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and anticonvulsant activity of some alkanamide derivatives

Ayse H. Tarikogullari
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
,
Sultan Kilic Fatma
2   Department of Pharmacology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey
,
Kevser Erol
2   Department of Pharmacology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey
,
Varol Pabuccuoglu
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
› Author Affiliations
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Publication History

Publication Date:
03 December 2011 (online)

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Abstract

A group of JV-phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1, 2, 4-triazole and imidazole rings at ω position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1, 2, 4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(lH-l, 2, 4-triazole-l-yl)-N-(2, 6-dimethylphenyl) acetamide.

Key words

Alkanamide - Anilide - Anticonvulsant drugs - Imidazole - Pyrazole - Triazole
 

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