A Convenient Synthesis of (1H-Azol-1-yl)piperidines

Abstract

A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds.

Key words

nitrogen heterocycles - azoles - piperidine - hydrogenation - molecular rigidity

• References

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