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Synthesis 2012; 44(11): 1628-1630
DOI: 10.1055/s-0031-1290985
DOI: 10.1055/s-0031-1290985
short paper
Application of the Kabachnik–Fields and Moedritzer–Irani Procedures for the Preparation of Bis(phosphonomethyl)amino- and Bis[(dimethoxyphosphoryl)-methyl]amino-Terminated Poly(ethylene glycol)
Further Information
Publication History
Received: 27 February 2012
Accepted after revision: 30 March 2012
Publication Date:
02 May 2012 (online)
Abstract
Bis[(dimethoxyphosphoryl)methyl)]amino- and bis(phosphonomethyl)amino-terminated samples of poly(ethylene glycol) (PEG) were prepared from commercially available PEG in fair-to-good yields by means of adaptations of the Moedritzer–Irani and Kabachnik–Fields procedures, respectively. An alternative route involving silylation of phosphonates and subsequent methanolysis to afford phosphonic acid groups was also examined.
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