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Synthesis 2012; 44(14): 2249-2254
DOI: 10.1055/s-0031-1290444
DOI: 10.1055/s-0031-1290444
paper
Tri- and Tetravalent Photoactivable Cross-Linking Agents
Further Information
Publication History
Received: 28 February 2012
Accepted after revision: 08 May 2012
Publication Date:
18 June 2012 (online)
Abstract
A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. Included are protocols for the synthesis of 1 to 6, 10, 12, 14, 15, 17, 21, 23, 24, 26, 30, 34, 36, and 13C NMR spectra.
- Supporting Information
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