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Synlett 2012(4): 622-626  
DOI: 10.1055/s-0031-1290341
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Regioselective AgNTf2-Catalyzed Intermolecular Hydroamination of Alkynes with Anilines

Xu Zhang, Bin Yang, Guangzhao Li, Xin Shu, Divyesh C. Mungra, Jin Zhu*
Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, P. R. of China
Fax: +86(25)83317761; e-Mail: jinz@nju.edu.cn;
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Publication History

Received 12 November 2011
Publication Date:
08 February 2012 (online)

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Abstract

A facile and economic method for the fully regioselective and high-yielding protocol for the hydroamination of unsymmetrical internal alkynes under mild reaction conditions with AgNTf2 was developed. The materials are easily available from commercial vendors, to give synthetically useful enamine derivatives efficiently. This strategy is efficient to build complex structures from simple starting materials in an environmentally compatible fashion.

Key words

AgNTf2 catalysis - intermolecular hydroamination - internal alkyne - enamine

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