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Synfacts 2011(12): 1320-1320  
DOI: 10.1055/s-0031-1289363
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Hydroamination of Dienes by Gold(I)/Menthol Cooperative Catalysis

Contributor(s): Mark Lautens, Patrick T. Franke
O. Kanno, W. Kuriyama, Z. J. Wang, F. D. Toste*
University of California at Berkeley, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The first example of Lewis acid activated Brønsted acidity in gold(I) catalysis is reported. Through a phosphine gold(I)/menthol catalyzed enantioselective diene hydroamination, pyrrolidine and piperidine adducts are formed in good yields.