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Synfacts 2011(12): 1269-1269  
DOI: 10.1055/s-0031-1289312
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Fesoterodine

Contributor(s): Philip Kocienski
O. Dirat et al.*
Pfizer Global Research and Development, Sandwich, UK
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

Fesoterodine (Toviaz®) is a mus­carinic antagonist prescribed for the treatment of overactive bladder. The key step in the synthesis depicted, a Friedel-Crafts alkylation of 4-hydroxy-methyl phenol (A) with cinnamaldehyde (B) mediated by N-methylpiperazine (C), has been accomplished on a 200 kg scale.