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Synfacts 2011(11): 1153-1153
DOI: 10.1055/s-0031-1289268
DOI: 10.1055/s-0031-1289268
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Spirastrellolide F Methyl Ester
S. Benson, M.-P. Collin, A. Arlt, B. Gabor, R. Goddard, A. Fürstner*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
Further Information
Publication History
Publication Date:
19 October 2011 (online)
Significance
The spirastrellolides are potent anti-mitotic agents. Their mode of action is by selective inhibition of the serine/threonine protein phosphatase PP2 A (IC50 ca. 1 nM).