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Synfacts 2011(11): 1245-1245  
DOI: 10.1055/s-0031-1289265
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Phosphoramide-Catalyzed Michael Addition of Oxindoles to Nitroolefins

Contributor(s): Benjamin List, Anna Lee
M. Ding, F. Zhou, Y.-L. Liu, C.-H. Wang, X.-L. Zhao, J. Zhou*
East China Normal University, Shanghai, P. R. of China
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Zhou and co-workers present a highly efficient asymmetric Michael addition of ­oxindoles to nitroolefins using phosphoramide catalyst A. The authors developed the new catalyst A on the basis of the cinchona alkaloid structure. Excellent diastereoselectivities and enantio­selectivities were observed under the reaction conditions.