Download PDF
Synfacts 2011(11): 1259-1259  
DOI: 10.1055/s-0031-1289241
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper Nanoparticles on Activated Carbon for Click Chemistry

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Shaheen M. Sarkar
F. Alonso*, Y. Moglie, G. Radivoy, M. Yus*
Universidad de Alicante, Spain and Universidad Nacional del Sur, Bahìa Blanca, Argentina
Further Information

Publication History

Publication Date:
19 October 2011 (online)

    Permissions and Reprints

Significance

Copper nanoparticles (CuNPs) were prepared on activated carbon by mixing CuCl2, lithium metal, and a catalytic amount (10 mol%) of 4,4′-di-tert-butylbiphenyl. The CuNPs-catalyzed (0.5 mol% Cu) Huisgen cycloaddition (click reaction) of alkyl, alkenyl, and benzylic halides/diazonium with sodium azide and terminal alkynes were carried out in water at 70 ˚C to give the corresponding triazoles 1 and 2 in up to 99% yields. Aromatic amines also gave the corres­ponding triazoles 3 in the presence of t-BuONO.