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Synfacts 2011(11): 1201-1201  
DOI: 10.1055/s-0031-1289217
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Thermally-Induced Cycloadditions of Diazo Compounds and Alkenes

Contributor(s): Mark Lautens, Hasnain A. Malik
S. R. Ovalles, J. H. Hansen, H. M. L. Davies*
Emory University, Atlanta, USA
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

There has been significant synthetic interest in the construction and utility of diazo compounds. A few classes of reactions that employ these reagents include cyclopropanations, C-H insertions, and ylide formations. Although diazo reagents tend to be thermally unstable, metal-catalyzed transformations employing aryldiazo acetates tend to be extremely selective and robust.