Download PDF
Synfacts 2011(11): 1227-1227  
DOI: 10.1055/s-0031-1289205
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Base-Mediated Transition-Metal-Free Alkynylation of Aryl Chlorides

Contributor(s): Paul Knochel, Nadja M. Barl
T. Truong, O. Daugulis*
University of Houston, USA
Further Information

Publication History

Publication Date:
19 October 2011 (online)

    Permissions and Reprints

Significance

Herein, two strategies for a transition-metal-free alkynylation of aryl chlorides are disclosed. The first set involves the use of TMPLi as base in pentane-THF, THF or diethyl ether at ambient temperature, while the second method uses metal alkoxides, such as t-BuONa and t-BuOK, in dioxane at temperatures up to 135 ˚C.