Download PDF
Klin Padiatr 2011; 223(06): 368-369
DOI: 10.1055/s-0031-1285880
Pictorial Essay
© Georg Thieme Verlag KG Stuttgart · New York

Acute Lymphoblastic Leukemia in a 10-Year-Old Boy With Cystic Fibrosis – Improvement of Pulmonary Function During Chemotherapy in spite of Intermittent Pseudomonas Aeruginosa Colonisation

Akute lymphoblastische Leukämie bei einem 10-jährigen Jungen mit zystischer Fibrose – Verbesserung der Lungenfunktion während Chemotherapie trotz intermittierender Pseudomonas-aeruginosa-Besiedlung
C. Dopfer
1   Department of Pediatrics, Cystic Fibrosis Centre, Jena University Hospital, Germany
,
K. Kentouche
2   Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
,
B. Gruhn
2   Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
,
R. Dopfer
3    Rehabilitation Hospital, Villingen-Schwenningen, Tannheim gGmbH, Germany
,
S. Becker
2   Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
,
H.-J. Mentzel
4   Pediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Germany
,
J. F. Beck
2   Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
,
J. G. Mainz
1   Department of Pediatrics, Cystic Fibrosis Centre, Jena University Hospital, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
19 October 2011 (online)

Also available at
    Permissions and Reprints

Background

Multiorgan involvement in cystic fibrosis (CF), including chronic airway infection with pathogens like Pseudomonas aeruginosa, is a critical risk factor in patients with malignancy during aggressive immunosuppressive therapy, and was therefore formerly associated with high mortality rates. A 10 year old boy with CF and acute lymphoblastic leukemia (ALL) underwent induction and reinduction treatment without severe infectious complications whereas lung function improved.

Key words

cystic fibrosis - leukemia - pulmonary function - osteopenia - cerebral venous thrombosis - liver toxicity

Schlüsselwörter

zystische Fibrose - Leukämie - Lungenfunktion - Osteopenie - Sinusvenenthrombose - Lebertoxizität
 

  • References

  • 1 Ballmann M, Junge S, von der Hardt H et al. Low-dose methotrexate for advanced pulmonary disease in patients with cystic fibrosis. Resp Med 2003; 97: 498-500
    CrossrefPubMedGoogle Scholar
  • 2 Bernbeck B, Wüller D, Janßen G et al. Symptoms of childhood acute lymphoblastic leukemia. Red flags to recognize leukemia in daily practice Klin padiatr 2009; 221: 369-373
    PubMedGoogle Scholar
  • 3 Biggs BG, Vaughan W, Colombo JL et al. Cystic fibrosis complicated by acute leukemia. Cancer 1986; 57: 2441-2443
    CrossrefPubMedGoogle Scholar
  • 4 Eigen H, Rosenstein BJ, FitzSimmons S et al. A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis. J Pediatr 1995; 126: 515-523
    CrossrefPubMedGoogle Scholar
  • 5 Eisen S, Painter H, Hyde SC et al. Clinical improvement in cystic fibrosis following anti-tumorous chemotherapy. Arch Dis Child 2004; 89 (12) 1179-1180
    CrossrefPubMedGoogle Scholar
  • 6 Lallemand JY, Stoven V, Annereau JP et al. Induction by antitumoral drugs of proteins that functionally complement CFTR: a novel therapy for cystic fibrosis? [Letter]. Lancet 1997; 350: 711-712
    PubMedGoogle Scholar
  • 7 Padua RA, Warren N, Grimshaw D et al. The cystic fibrosis delta F508 gene mutation and cancer. Hum Mutat 1997; 10 (01) 45-48
    CrossrefPubMedGoogle Scholar
  • 8 Rizzari C, Conter V, Jankovic M et al. Acute lymphoblastic leukemia in a child with cystic fibrosis. Haematologica 1992; 77: 427-429
    PubMedGoogle Scholar
  • 9 Sermet-Gaudelus I, Kessler R, Stoven V et al. Dramatic improvement of cystic fibrosis during and after antitumourous chemotherapy: a report of three cases [abstract]. Pediatr Pulmonol 1998; 17 (suppl) 219-220
    PubMedGoogle Scholar
  • 10 Spix C, Schulze-Rath R, Kaatsch P et al. Case-control study on risk factors for leukaemia and brain tumours in children under 5 years in Germany. Klin Padiatr 2009; 221: 362-368
    Article in Thieme ConnectPubMedGoogle Scholar