Arzneimittelreaktionen an der Haut – Klinik, Diagnose und Therapie

Arzneimittelreaktionen sind definitionsgemäß nicht erwünschte und nicht geplante Wirkungen eines Medikaments. Adverse kutane Reaktionen auf Arzneimittel bei Hund und Katze sind eher selten, können aber grundsätzlich auf jeden Wirkstoff auftreten und prinzipiell jede andere Dermatose imitieren. Bei jedem Tier mit länger dauernden (Haut-)Problemen, das medikamentös behandelt worden ist, sollten solche Reaktionen differenzialdiagnostisch in Betracht gezogen werden.

• Literatur

• 1 Abe R. Toxic epidermal necrolysis and Stevens-Johnson syndrome: soluble Fas ligand involvement in the pathomechanisms of these diseases. J Dermatol Sci 2008; 52: 151-159
• 2 Aslanzadeh J, Helm KF, Espy MJ et al. Detection of HSV-specific DNA in biopsy tissue of patients with erythema multiforme by polymerase chain reaction. Br J Dermatol 1992; 126: 19-23
• 3 Brice SL, Krzemien D, Weston WL et al. Detection of herpes simplex virus DNA in cutaneous lesions of erythema multiforme. J Ivest Dermatol 1989; 93: 183-187
• 4 Byrne KP, Giger U. Use of human immunoglobulin for treatment of severe erythema multiforme in a cat. J Am Vet Med Assoc 2002; 220: 197-201 , 183–194
• 5 French LE. Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. Allergol Int 2006; 59: 9-16
• 6 Hanley CS, Simmons HA, Wallace RS et al. Erythema multiforme in a spotted hyena (Crocuta crocuta). J Zoo Wildl Med 2005; 36: 515-519
• 7 Hinn AC, Olivry T, Luther PB et al. Erythema multiforme, Steven-Johnson syndrome, and toxic epidermal necrolysis in the dog: clinical classification, drug exposure, and histopathological correlations. J Vet Allergy Clin Immunol 1998; 6
• 8 Leaute-Labreze C, Lamireau T, Chawki D et al. Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome. Arch Dis Child 2000; 83: 347-352
• 9 Nassif A, Benussan A, Dorothee G et al Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis. J Invest Dermatol 2002; 118: 728-733
• 10 Noli C, Scarampella F. Arzneimittelexantheme. Praktische Dermatologie bei Hund und Katze. Hannover: Schlütersche; 2005: 289-297
• 11 Scott DW, Miller WHJ, Goldschmidt MH et al. Toxic epidermal necrolysis in two dogs and a cat. J Am Anim Hosp Assoc 1979; 19: 453-459
• 12 Scott DW, Miller WHJ. Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary medicine (1988–96). Vet Dermatol 1999; 10: 297-309
• 13 Tatnall FM, Schofield JK, Leigh IM. A doubleblind, placebo-controlled trial of continuous acyclovir therapy in recurrent erythema multiforme. BR J Dermatol 1995; 132: 267-270
• 14 Tay YK, Huiff JC, Weston WL. Mycoplasma pneumoniae infection is associated with Stevens-Johnson syndrome, not erythema multiforme (von Hebra). J Am Acad Dermatol 1996; 35: 757-760
• 15 Thomas BA. The so-called Stevens-Johnson syndrome. BR Med J 1950; 1: 1393-1397
• 16 Trotman TK, Phililips H, Fordyce H et al. Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs. J Am Anim Hosp Assoc 2006; 42: 312-320
• 17 Wolf R, Wolf D, Davidovici B. In the pursuit of classifying severe cutaneous adverse reactions. Clin Dermatol 2007; 25: 348-349
• 18 Yager JA. Erythema multiforme in humans and animals. Proceedings 23rd Annual Congress of the ECVD-ESVD on Veterinary Dermotology. Bled: 17– 19.09.2009: 21-29
• 19 Yeruham I, Perl S, Elad D. Nine cases of idiopathic toxic epidermal necrolysis in cattle in Israel. Zentralbl Veterinarmed B 1999; 46: 493-498
• 20 Zeitouni NC, Funaro D, Cloutier RA et al. Redefining Rowell’s syndrome. BR J Dermatol 2000; 142: 343-346