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Synfacts 2011(9): 0968-0968  
DOI: 10.1055/s-0030-1261037
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Ketone Hydrogenation Using a Novel Ruthenium Catalyst

Contributor(s): Mark Lautens, Stephen G. Newman
K. Matsumura, N. Arai, K. Hori, T. Saito, N. Sayo, T. Ohkuma*
Hokkaido University, Sapporo and Takasago International Corporation, Kanagawa, Japan
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

Ruthenium catalysts bearing di­phosphine and diamine ligands are particularly effective at mediating asymmetric ketone hydrogenation (see Review below). The authors present a new catalyst that shows superior reactivity compared to previous generations.

Review: R. Noyori, T. Ohkuma Angew. Chem. Int. Ed. 2001, 40, 40-75.