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Synfacts 2011(9): 0971-0971
DOI: 10.1055/s-0030-1261011
DOI: 10.1055/s-0030-1261011
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans
J. Wang, E. A. Crane, K. A. Scheidt*
Northwestern University, Evanston, USA
Further Information
Publication History
Publication Date:
19 August 2011 (online)
Significance
The authors report a synthesis of spirooxindole pyrans through a Brønsted acid catalyzed Prins cyclization. The reaction is highly diastereoselective and the products comprise an important structural motif. Several reactions of the products are reported to yield a variety of interesting derivatives.