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Synfacts 2011(8): 0821-0821  
DOI: 10.1055/s-0030-1260678
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of P13K Inhibitors

Contributor(s): Philip Kocienski
Q. Huang*, P. F. Richardson, N. W. Sach, J. Zhu, K. K.-C. Liu, G. L. Smith, D. M. Bowles
Pfizer Global R&D, San Diego and Groton, USA
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Publication History

Publication Date:
20 July 2011 (online)

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Significance

The target molecule is one of three P13K receptor antagonists that were promising candidates for the treatment of some types of cancer. The route depicted incorporates a difficult late-stage Suzuki-Miyaura coupling that enables wide variation from the common intermediate iodo­thiophene E.