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Synfacts 2011(7): 0752-0752  
DOI: 10.1055/s-0030-1260662
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Ligand for Pd-Catalyzed Enantioselective Intramolecular Arylation

Contributor(s): Hisashi Yamamoto, Jiajing Tan
L. Liu, N. Ishida, S. Ashida, M. Murakami*
Kyoto University, Japan
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

A novel chiral NHC ligand bearing a 2,2′-bisquinoline-based C 2-symmmetric structure was developed and can be used for asymmetric palladium-catalyzed intramolecular α-arylation of amides to give substituted oxindoles with good to excellent yields and enantioselectivities.