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Synfacts 2011(7): 0747-0747
DOI: 10.1055/s-0030-1260658
DOI: 10.1055/s-0030-1260658
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Bifunctional Lewis Acid/Enamine Catalysis of Hetero-Diels-Alder Reaction
Z. Xu, L. Liu, K. Wheeler, H. Wang*
Miami University, Oxford and Eastern Illinois University, Charleston, USA
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
The combination of metal Lewis acid catalysis and organocatalysis in one reaction is attractive and may allow entirely new reactions to occur. In this report, a bifunctional catalyst that can chelate with the metal and generate enamine at the same time is introduced to a hetero-Diels-Alder reaction. The excellent efficiency and stereoselectivity nicely demonstrated the utility of such a strategy.