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Synfacts 2011(7): 0755-0755  
DOI: 10.1055/s-0030-1260656
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Scandium-Catalyzed Conjugate Addition of Hydrazides to Chalcones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
J. Jiang, Y. Cai, W. Chen, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Aza-Michael reactions with hydrazides lead to pharmacologically active molecules. This reaction is particularly challenging due to the regioselectivity between two competitive amines. This paper describes a scandium catalyst system that achieves highly enantioselective and regioselective products.