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Synfacts 2011(7): 0759-0759  
DOI: 10.1055/s-0030-1260654
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric O-H Insertion of α-Diazo Phosphonates

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
S.-F. Zhu, W.-Q. Chen, Q.-Q. Zhang, H.-X. Mao, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Asymmetric O-H insertions of α-diazo esters are well established; however, O-H ­insertion of α-diazo phosphonates has not been explored due to the high stability of α-diazo phosphonates. In this report, the authors achieved the first enantioselective O-H insertion reaction to these phosphonates.