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Synfacts 2011(7): 0714-0714
DOI: 10.1055/s-0030-1260511
DOI: 10.1055/s-0030-1260511
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Pyrimidin-4(3H)-ones via Vilsmeier-Haack Reaction
R. Zhang, D. Zhang, Y. Liang, G. Zhou, D. Dong*
Changchun Institute of Applied Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
Described is a one-pot efficient synthesis of pyrimidin-4(3H)-ones 2 via Vilsmeier-Haack reaction of readily available aminopropenamides 1. This process is proposed to involve a halogenation, formylation, and intramolecular nucleophilic cyclization sequence. The reaction scope and limitations were not well investigated.