Pd-Catalyzed Decarboxylative Cross-Coupling to Yield Aryl
Ketones

M. Li; C. Wang; H. Ge

doi:10.1055/s-0030-1260501

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Synfacts 2011(7): 0776-0776
DOI: 10.1055/s-0030-1260501

Metal-Mediated Synthesis

Pd-Catalyzed Decarboxylative Cross-Coupling to Yield Aryl Ketones

Contributor(s): Paul Knochel, Andreas K. Steib
M. Li, C. Wang, H. Ge*
Indiana University Purdue University Indianapolis, USA

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Publication History

Publication Date:
17 June 2011 (online)

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Significance

A novel palladium-catalyzed decarboxylative cross-coupling of potassium aryltrifluoroborates with α-oxocarboxylic acids to afford aryl ketones has been disclosed. A combination of catalytic Pd(OAc)₂ with stoichiometric K₂S₂O₈ was found to be the most efficient system for the reaction.