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Synfacts 2011(7): 0701-0701  
DOI: 10.1055/s-0030-1260488
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-7-Isocyanoamphilecta-11(20),15-diene

Contributor(s): Steven V. Ley, Philippa B. Cranwell
H. Miyaoka*, Y. Okubo
Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

(±)-7-Isocyanoamphilecta-11(20),15-diene was isolated in Australia from the tropical marine sponge Cymbastela hooperi. Other compounds in the amphilectane-type diterpenoid family of natural products have been shown to have a wide range of biological activity including antimicrobial, anti-inflammatory, antimalarial and antituberculosis.