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Synfacts 2011(6): 0675-0675  
DOI: 10.1055/s-0030-1260428
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Kinetic Resolution of Allylic Amines via a Dual-Catalysis Approach

Contributor(s): Benjamin List, Anna Lee
E. G. Klauber, N. Mittal, T. K. Shah, D. Seidel*
The State University of New Jersey, Piscataway, USA
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

Seidel and co-workers report the kinetic resolution of allylic amines via a dual-catalyst system. A kinetic resolution of highly nucleophilic or reactive amines, such as primary allylic amines, has remained elusive. On the basis of their previous studies, the authors found a catalytic combination for the acylation of amines allowing for kinetic resolution. The first nonenzymatic kinetic resolution of allylic amines was accomplished by this dual-catalyst system.