Download PDF
Synfacts 2011(6): 0636-0636  
DOI: 10.1055/s-0030-1260391
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral γ-Butyrolactones by a Domino Aldol-Cyclization Reaction

Contributor(s): Mark Lautens, Stephen G. Newman
A. Yanagisawa*, N. Kushihara, K. Yoshida
Chiba University, Japan
Further Information

Publication History

Publication Date:
19 May 2011 (online)

    Permissions and Reprints

Significance

Chiral lactones are found in numerous biologically active natural products and are useful precursors for the synthesis of many interesting molecules. Based on their previous work on asymmetric tin-catalyzed aldol reactions (Chem. Eur. J. 2009, 15, 11450), the authors have developed a domino approach to prepare γ-butyrolactones in good yields, regio- and enantioselectivity.