C-H Alkylation of Heteroarenes with Alkyl- and Alkoxymethyltrifluoroborates

G. A. Molander; V. Colombel; V. A. Braz

doi:10.1055/s-0030-1260365

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Synfacts 2011(6): 0657-0657
DOI: 10.1055/s-0030-1260365

Metal-Mediated Synthesis

C-H Alkylation of Heteroarenes with Alkyl- and Alkoxymethyltrifluoroborates

Contributor(s): Paul Knochel, Andreas K. Steib
G. A. Molander*, V. Colombel, V. A. Braz
University of Pennsylvania, Philadelphia, USA

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Publication History

Publication Date:
19 May 2011 (online)

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Significance

A new direct C-H alkylation of various heterocycles using potassium alkyl- and alkoxymethyltrifluoroborates is described. The highest yields were obtained with Mn(OAc)₃ as oxidant in the presence of trifluoroacetic acid in a 1:1 mixture of acetic acid and water.