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Synfacts 2011(5): 0516-0516  
DOI: 10.1055/s-0030-1259867
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed C-H Insertion in α-Sulfonyl Cyclopentanone Synthesis

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
C. N. Slattery, A. R. Maguire*
University College Cork, Ireland
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

The authors extend their work on C-H insertion of α-diazosulfones to the enantio­selective C-H insertion of α-diazo-β-keto sulfones using a copper bis(oxazoline) complex. Intramolecular formation of these α-sulfonyl cyclopentanones occurs with up to 82% ee.