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Synfacts 2011(5): 0565-0565  
DOI: 10.1055/s-0030-1259810
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Polymer-Supported Gold(I) Catalysts for Intramolecular Cyclization

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Shaheen M. Sarkar
M. Egi, K. Azechi, S. Akai*
University of Shizuoka, Japan
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Polystyrene-immobilized cationic gold(I) catalysts 2a and 2b were prepared and exhibited high catalytic activity for the intramolecular ring-forming reactions leading to heterocycles 4 and 6, and a cycloalkane 8 (71-98% yield). Catalyst 2a was applied to a flow (0.065 M, 1-2.5 mL/min) reactor system to achieve rapid and continuous production of 4a [92%: flow rate = 1.0 mL/min, 89%: flow rate = 2.5 mL/min (4.04 g production within 30 min)].