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Synfacts 2011(5): 0564-0564  
DOI: 10.1055/s-0030-1259807
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Copper Metal-Organic Framework Catalyst for Henry Reaction

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Yoshinari Yuyama
L. X. Shi, C. D. Wu*
Zhejiang University, Hangzhou, P. R. of China
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Copper MOF 1 was prepared from Cu(NO3)2 and pyridine carboxylates, which was used for the Henry reaction of aryl aldehydes and nitroalkanes. Thus, the reaction of aryl aldehydes and nitroalkanes was performed with 1 under solvent-free conditions to give the corresponding β-nitroalcohols in 45-85% yield (5 examples).